1. Cystamine was reduced to the corresponding thiol by rat liver mitochondria, even in the presence of rotenone or antimycin A. 2. The reduction of disulphides was stimulated by the accumulation of NADH or by the addition of NADH to osmotically ;shocked' mitochondria. 3. Energy made available by oxidative phosphorylation was not essential for the reduction of disulphides. 4. Cystamine was not r...

To thrive in diverse environments, bacteria must shift their metabolic output in response to nutrient bioavailability. In many bacterial species, such changes in metabolic flux depend upon lipoic acid, a cofactor required for the activity of enzyme complexes involved in glycolysis, the citric acid cycle, glycine catabolism, and branched chain fatty acid biosynthesis. The requirement of lipoic a...

The paper presents an analysis of current literature data on the use R-enantiomer α-lipoic acid as antihypertensive treatment in patients with hypertension and metabolic syndrome. An was carried out its antiinflammatory agent inflammatory diseases. Currently, a very important aspect researches is possibility using R-α-lipoic micronutrient therapeutic for diabetic polyneuropathy neurodegenerativ...