Abstract Background Diabetes mellitus (DM) is a growing disease across the world; diabetes complex metabolic disorder in which blood glucose concentration level increases and continue for prolonged period due to decrease secretion of insulin or action, resulting carbohydrate, lipid, protein metabolism. The plant-related bioactive compounds have proven their efficacy with least toxicities can be...

Two new pyrrolidine alkaloids, broussonetines G and H, were isolated from the branches of Broussonetia kazinoki SIEB. (Moraceae). Broussonetines G and H were formulated as 2 beta-hydroxymethyl-3 alpha, 4 beta-dihydroxy-5 alpha-(1-hydroxy- 6:10;10:13-diepoxytridecyl)-pyrrolidine (1) and 2 beta-hydroxymethyl-3 alpha, 4 beta-dihydroxy-5 alpha-(1-hydroxy- 5:9;9:13-diepoxytridecyl)-pyrrolidine (2), ...

1. The activities of lysosomal enzymes in the cortexes and medullas and the principal subcellular fractions of rat kidney were measured. 2. A method is described for the isolation of rat-kidney lysosomes and a detailed analysis of the enzymic composition of the lysosomes is reported. Enzyme analysis of the other principal subcellular fractions is included for comparison. 3. Studies of the distr...

AIM/INTRODUCTION To assess the overall safety and efficacy of lixisenatide in combination with background oral antidiabetic drug treatment in Japanese patients with type 2 diabetes, as required by Japanese guidelines. MATERIALS AND METHODS A phase 3, multicenter, uncontrolled, open-label, four-arm, parallel-group study of Japanese outpatients with type 2 diabetes was carried out; patients rec...

The Dayak tribe in Kalimantan has long used bawang dayak as a traditional cure for various degenerative diseases. Previous research showed that bulb an active compound can inhibit the enzyme alpha-glucosidase, known alpha-glucosidase inhibitor (AGI). Compounds have such ability potential controlling blood glucose level diabetes mellitus. This aims to study effective dosage of aqueous extract an...