An investigation into the effect of sodium on alloxan diabetes was prompted by the following observations. The beneficial effect of sodium chloride for diabetic persons was demonstrated by McQuarrie et al. (1). They found that an increased intake of sodium chloride resulted in a decrease in the fasting level of blood sugar and in glycosuria. Sayers et al. (2) showed that the low glucose toleran...

The aim of the present study was to investigate the effects of Mangifera indica leaves extract on the kidney function parameters in alloxan induced diabetic Swiss albino mice. Forty five albino mice (weighing 28 to 32 g) were randomly divided into control, alloxan treated and Mangifera indica treated mice group. Diabetes was induced in mice by injecting intraperitoneally alloxan monohydrate at ...

Trehalase activity was determined in serum, liver, and kidney in alloxan treated Swiss mice and in homozygous (Ob/Ob, Db/Db) and heterozygous (Ob/+, Db/m+) diabetic mice. Both alloxan and genetic diabetic mice exhibited a large increase in serum and liver trehalase activity with no change in kidney trehalase activity. The heterozygotes (Ob/+, Db/m+) showed only a slight increase of enzyme activ...

The position and number of preganglionic somata innervating the insulin-secreting beta-cells of the endocrine pancreas were investigated in Wistar rats. This question was approached by comparing the innervation of the pancreas of normal rats with the innervation of the pancreas in alloxan-induced diabetic animals. The presumption was made that alloxan treatment destroys the beta-cells of the is...

The occurrence of DNA fragmentation in lymphocytes obtained from alloxan-induced diabetic rats and diabetic patients was investigated. A high proportion of apoptotic lymphocytes in diabetic states may explain the impaired immune function in poorly controlled diabetic patients. Rat mesenteric lymph node lymphocytes were analysed for DNA fragmentation by using flow cytometry and agarose gel, and ...

Mulberry leaves (Morus alba L.) are a traditional Chinese medicine for blood serum glucose reduction. This study evaluated the protective effects of mulberry flavonoids on sciatic nerve in alloxan-induced diabetic rats. In this study, 80 Sprague-Dawley rats were divided into five groups: A (control), B (diabetic treated with saline), C-D (diabetic treated with 0.3, 0.1 g/kg mulberry flavonoids ...

– Objective: The aim of this investigation was studying the influence of glucose metabolic control on diabetic nephropathy. The authors observed the effect of acarbose, insulin, and both drugs on the metabolic control and development of mesangial enlargement of kidney glomeruli in alloxan-diabetic rats. Methods: Five groups of Wistar rats were used: normal rats (N), non-treated alloxan-diabetic...

Suspensions of islet cells were prepared by shaking pancreatic islets from non-inbred ob/ob mice in a Ca2+-free buffer. The cells were incubated with or without 20 mM-alloxan, and subsequently with Trypan Blue. The uptake of Trypan Blue by cell nuclei was analysed by microscope photometry and by counting the frequency of cells appearing stained on visual inspection. Cells classified as stained ...

Introduction: Costus speciosus is a common plant used for the treatment of diabetes mellitus and various other ailments in traditional medicine Sri Lanka. The present study was conducted to investigate hypoglycemic effect leaves C. both normal alloxan induced male Wistar diabetic rat models. Methods: A methanolic extract produced preliminary phytochemicals screening. Methanol further partitione...