‘‘He inflicts none of those small pains and discomforts which irregular men scatter about them and which in the aggregate so often become formidable obstacles both to happiness and utility; while on the contrary he bestows all the pleasures, and inspires all that ease of mind on those around him or connected with him, with perfect consistency, and (if such a word might be framed) absolute relia...

The goddess of health, Hygieia, was much venerated, understandably, in the ancient Greek world; her numerous statues usually represented her holding a serpent. Hygieia's father was Aesculapius, the god of medicine, who developed his clinical skills as physician to the Argonauts and made use of herbs in treatment; the serpent and the cock were considered sacred to him. So the Greeks, when wantin...

We show that classification rules used in ordinal regression are equivalent to a certain class of linear multi-class classifiers. This observation not only allows to design new learning algorithms for ordinal regression using existing methods for multi-class classification but it also allows to derive new models for ordinal regression. For example, one can convert learning of ordinal classifier...

The competition among shopping malls is getting increasingly more intense.In order to enhance corporate competitiveness and profitability, how toretain key loyal customers has become an important issue for the managers ofshopping malls. Customer loyalty programs are a universal practice. Thisstudy proposes an analytical model for developing the strategic management...

Biomarker subpopulations have become increasingly important for drug development in targeted therapies. The use of biomarkers has the potential to facilitate more effective outcomes by guiding patient selection appropriately, thus enhancing benefit-risk profile and improving trial power. Studying a broad population simultaneously with one allows determine which treatment is goal making approved...