Monro, J. L., Gavin, J. B., and Barratt-Boyes, B. G. (1974). Thorax, 29, 323-328. A comparison of antibiotic-sterilized, stent-mounted pulmonary and aortic valve allografts in the mitral region of dogs. The mitral valves of 40 dogs were replaced with antibioticsterilized, stent-mounted semilunar valve allografts. Twenty grafts were pulmonary valves and 20 were aortic valves. Six dogs in each gr...

Indications for the use of osteochondral allografts for orthopaedic surgical applications are increasing with improved surgical techniques and advancing experience. Modern tissue banks have developed harvesting, processing, and storage methods that ensure an adequate, safe supply of grafts. Continued research is necessary to find a technique that maximizes chondrocyte viability and metabol...

Donor/recipient MHC class II matching permits survival of experimental allografts without permanent immunosuppression, but is not clinically applicable due to the extensive polymorphism of this locus. As an alternative, we have tested a gene therapy approach in a preclinical animal model to determine whether expression of allogeneic class II transgenes (Tg's) in recipient bone marrow cells woul...

THE SPECIFIC immunologic non-reactivity to allografts that was first produced in fetal or neonatal mice by Billingham, Brent, and Medawar,l and. ultimately, in human bone marrow recipients25 has remained enigmatic for nearly a half century. Without first understanding this "acquired tolerance," and. especially, the "acceptance" of organ allografts it is folly to dream of a future that includes ...

The results are reported of an audit of allografts collected in the first 18 months of the Leicester Bone Bank. We retrieved 161 femoral heads at primary arthroplasty of which 103 were implanted into 59 patients. There were deep infections in two recipients and wound infections in five. In two of these cases, culture of the femoral head at implantation was positive but the organisms grown were ...

Structural bone allografts have become an alternative in the treatment of limb bone tumours with a chance of limb-saving surgery. We present an observational retrospective study on the use of structural bone allografts in bone tumours of the long bones in our hospital between January 1993 and January 2010, with a sample of 37 patients subjected to this surgical technique. After obtaining clinic...

Radiation sterilized human amniotic membrane allografts are used as biological dressing of wounds in rehabilitative surgery. The is many different clinical situations such as: heat burn, chemical burns, diabetic wound/ foot ulcer, leprotic abdominal wall reconstruction, pterigium removal site, peripheral corneal the management pressure sore, etc.Non-viable lyophilized/oven-dried radiation could...

PurposePlatelets may sequester free RNA and could therefore be used as a biomarker for monitoring of allografts after transplantation. The purpose this study is to address the correspondent usability platelets liquid biopsy distinguish recipients with acutely rejecting from healthy allografts.MethodsWe prospectively collected recipient peripheral blood endomyocardial biopsies (EMB) 50 at time s...

In the present study we used an adoptive transfer model with athymic nude mice to characterize the T cells involved in initiating and mediating skin allograft rejection. It was found that skin allograft rejection in nude mice required the transfer of immunocompetent T cells and that such reconstitution did not itself stimulate the appearance of T cells derived from the nude host. Reconstitution...

Pancreatic islet transplantation is a promising potential cure for type 1 diabetes (T1D). Islet allografts can survive long term in the liver parenchyma. Here we show that liver NK1.1+ cells induce allograft tolerance in a T1D mouse model. The tolerogenic effects of NK1.1+ cells are mediated through IL-22 production, which enhances allograft survival and increases insulin secretion. Increased e...