Background Mandibular continuity defects occur after tumor resection, maxillofacial injury, or osteomyelitis. Despite the current availability of a plethora of treatment modalities, bone substitutes, and various clinical adjuncts, an exact reconstructive recapitulation of large bony defects continues to be beyond reach. In this clinical pilot study, we report a novel method for reconstruction ...

background: burkitt lymphoma is a common subtype of non-hodgkin lymphoma in children. it has a rapid and aggressive clinical course with frequent involvement of bone marrow and central nervous system. systemic chemotherapy is the mainstay of the treatment for this malignancy in children. in this systematic review, we discuss autologous and allogeneic hematopoietic stem cell transplantation (hsc...

Mucormycosis is a fungal infection caused by opportunistic fungi of the phylum Glomeromycota, subphylum Mucormycotina. In developed countries, it affects patients with haematological malignancies undergoing chemotherapy and those who have received allogenic stem cell transplants, while in developing countries seen uncontrolled diabetes mellitus. Herein, we report case cutaneous mucormycosis 67y...

Tracheal stenosis represents a significant challenge. Surgeons continue to search for appropriate reconstructive techniques and grafting materials long tracheal segment reconstruction. Grafts can be classified as synthetic, allogenic, autogenic, transplant, engineered. Although none of these grafts have provided overwhelming success, acellular composite engineered shown early promise applied in...

Among advanced melanomas, approximately 60% of the patients present with immunologic ignorance or intrinsic induction tumors need other therapeutic approaches to change an immunologically “cold tumor” “hot by attracting T cells into tumors. We have established immune cell therapy immortalized induced pluripotent stem–cell (iPSC)–derived proliferating myeloid (iPSC–pMCs). The benefits using iPSC...

We present a case of disruption of the posterolateral corner of the knee with avulsion of the tendon of biceps femoris. Repair and reconstruction included an allogenic tendon graft to replace the posterior cruciate ligament. Surgery was followed by a complete common peroneal nerve palsy. Revision surgery revealed that the nerve had been displaced anteriorly by avulsion of the biceps tendon and ...

Contrary to previous findings, we found no significant differentiation of splenocytes into pancreatic islet cells in nonobese diabetic (NOD) mice treated with an immune adjuvant and allogenic spleen cells. We show that our single-nucleotide polymorphism assay has the requisite sensitivity to support our contention. The experiments of Faustman et al. lack adequate controls, and we maintain that ...

Paecilomyces variotii is a commonly occurring species in air and food, and it is also associated with many types of human infections. Pneumonia due to Paecilomyces variotii has been rarely reported in the medical literature. The authors report a 48-year-old patient with refractory lymphoma who underwent allogenic hematopoietic cell transplantation and developed pneumonia due to Paecilomyces var...