Background Efficacy testing of immunotherapy in field studies is often hampered by variation of airborne allergens. Standardized allergen exposure in challenge chamber settings might overcome aforementioned limitations. However, airborne allergens such as house dust mite (HDM) or cat allergen are not available as standardized source material with distinct particle size. Therefore, we developed ...

Allergen-specific immunotherapy (SIT) is the only allergen-specific treatment for allergy. It can prevent progression of the disease and has a long-lasting therapeutic effect. Since SIT is allergen-specific, the identification of the disease-eliciting allergen is an essential prerequisite for the accurate prescription of treatment. Diagnostic tests based on allergen extracts consist of mixtures...

Abstract Background A perennial house dust mite-associated allergic rhinitis has a major impact on the quality of life patients and is associated with high socioeconomic burden. The most common symptoms include runny nose nasal congestion, sneezing, itching nose, mouth and/or throat, ocular symptoms. Affected often develop bronchial asthma. Therapy options for allergen avoidance, symptomatic tr...

Objectives: Allergen-specific immunotherapy (AIT) has been considered the most effective treatment for IgE mediated allergies, especially respiratory allergies. Several biomarkers have developed to evaluate clinical efficacy of AIT, yet none them thoroughly validated. So our objective here is investigate usefulness periostin as a biomaker monitoring allergen immunotherapy. Materials and methods...

BACKGROUND Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy. OBJECTIVE The aim of this study was to appreciate and correlate the local and spirometric changes elicited by the allergen-specific nasal provocation test (NPT) to define practical and feasible guidelines for the allergist/immunologist to demonstrate ...

BACKGROUND Allergen-specific immunotherapy represents the only disease-modifying treatment for allergic diseases. We and others have previously demonstrated that intralymphatic immunotherapy (ILIT), a less time-consuming alternative to conventional subcutaneous immunotherapy (SCIT), is safe and effective. However, this has recently been disputed. The aim of this study was therefore to expand ou...

Preparation of high quality allergen extracts is essential for the diagnosis and immunotherapy of allergic disorders. Standardization of allergen extracts concerns determination of the allergen unit, development of reference material and measurement of the overall IgE binding capacity of an allergen extract. Recently, quantification of individual allergens has been the main focus of allergen st...

PURPOSE We studied the efficacy of eyedrops as local ocular immunotherapy against experimental allergic conjunctivitis. METHODS Guinea pigs were sensitized with an intraperitoneal injection of ovalbumin (OA). Three weeks after the sensitization, a low concentration (10 microg/mL) of OA eyedrops was administered once a day for 3 weeks. Six weeks after the sensitization, an allergic inflammatio...