It is presumed that uric acid is an end-product of human metabolism and, as such, is not further catabolized. This presumption is based largely upon indirect evidence such as the failure to demonstrate uricase in human tissues and the uncertain r81e of allantoin in human metabolism. On the other hand, Folin presented evidence that uric acid intravenously injected into humans could not be quanti...

Miller, Sara E. M.S., Purdue University, August 2012. Functional Characterization of Two Putative Nucleobase Transporters in Arabidopsis Using Heterologous Complementation in Yeast. Major Professor: George S. Mourad. To identify the substrate profile function for AtNAT5, one of the twelve members of the NAT/NCS2 gene family putatively identified to transport xanthine and/or uric acid, and to id...

Andrographis paniculata is an annual herb and widely cultivated in Southeast Asian countries for its medicinal use. In recent investigations, A. paniculata was found to be effective against Type 1 diabetes mellitus (Type 1 DM). Here, we used a non-genetic out-bred Sprague-Dawley rat model to test the antidiabetic activity of A. paniculata against Type 2 diabetes mellitus (Type 2 DM). Proton Nuc...

Growth experiments showed that adenine and hypoxanthine can be used as nitrogen sources by several strains of K. pneumoniae under aerobic conditions. The assimilation of all nitrogens from these purines indicates that the catabolic pathway is complete and proceeds past allantoin. Here we identify the genetic system responsible for the oxidation of hypoxanthine to allantoin in K. pneumoniae. The...

The urinary excretion of allantoin and uric acid was greatly increased in rats bear ing Walker carcinoma 256. The increase was greater with more advanced tumor growth. A similar increase was also observed in the allantoin concentration of the plasma and liver of these rats. An increase in the RNA and DNA content and a decrease in the RNA/DNA ratio were found in the muscle of the tumor-bearing a...

The ureides, allantoin and allantoic acid, represented major fractions of the soluble nitrogen pool of nodulated plants of cowpea ( Vigna unuiulata [L.] Walp. cv. Caloona) throughout vegetative and reproductive growth. Stem and petioles were the principal sites of ureide accumulation, especialy in early fruiting. Labeling studies using 14C02 and 15N2 and incubation periods of 25 to 245 minutes ...