Alkaptonuria is disorder of tyrosine metabolism due to deficiency of homogentisic oxidase characterized by excretion of homogentisic acid in urine, deposition of oxidized homogensitate pigments in connective tissues and articular cartilages (ochronosis). The result is dark pigmentation and weakening of the tissues resulting in chronic inflammation and osteoarthritis. Management of alkaptonuric ...

Alkaptonuria is an autosomal recessive disorder caused by the deficiency of homogentisate 1.2 dioxygenase activity. The clinical presentation shows an ochronotic pigment which is deposited in all connective tissues, including in cartilage, particularly. The knee is the most common site of peripheral abnormality. There is currently no definitive cure for alkaptonuric ochronosis. In this article,...

Petrification of the auricle is a recognized and distinct pathological entity. This involves ossificationorcalcification of the auricular cartilage resulting in hardening of the auricle which is clinically evident on palpation and can be confirmed through radiological imaging. The aetiology of this unusual phenomenon is varied and includes both local and systemic causes. Systemic conditions ass...