نتایج جستجو برای: ali as
تعداد نتایج: 5648128 فیلتر نتایج به سال:
Geranylgeranyl transferase I (GGTase I), which modifies proteins containing the sequence Cys-Ali-Ali-Leu (Ali: aliphatic) at their C-termini, is indispensable for growth in the budding yeast Saccharomyces cerevisiae. We report here that GGTase I is no longer essential when Rho1p and Cdc42p are simultaneously overproduced. The lethality of a GGTase I deletion is most efficiently suppressed by pr...
Acute lung injury (ALI) is a life-threatening syndrome that causes high morbidity and mortality worldwide. ALI is characterized by increased permeability of the alveolar-capillary membrane, edema, uncontrolled neutrophils migration to the lung, and diffuse alveolar damage, leading to acute hypoxemic respiratory failure. Although corticosteroids remain the mainstay of ALI treatment, they cause s...
Acute lung injury (ALI) is a critical syndrome associated with respiratory dysfunction, and neutrophils are considered to be central to the pathogenesis of ALI. This study investigated the effects of glutamine (Gln) on neutrophil recruitment in a model of lipopolysaccharide (LPS)-induced ALI. C57BL/6 mice were fed a standard diet either with casein as the nitrogen source or with 25% of total ni...
OBJECTIVES We observed early acute lung injury (ALI) after a switch from veno-arterial extracorporeal life support (VA-ECLS) to long-term mechanical circulatory support (MCS). The aim of our study was to analyse the frequency, impact on mortality and characteristics of patients presenting ALI after MCS implantation in the bridge-to-bridge (BTB) strategy. METHODS We retrospectively analysed da...
RATIONALE Acute lung injury (ALI) that develops 6 hours after transfusion (TRALI) is the leading cause of transfusion-related mortality. Several transfusion characteristics have been postulated as risk factors for TRALI, but the evidence is limited to retrospective studies. OBJECTIVES To compare patient and transfusion risk factors between patients who do and do not develop ALI. METHODS In ...
دریاچه مهارلو یکی از دریاچه های شور ایران است که در استان فارس و در 23 کیلومتری جنوب شرقی شیراز قرار دارد و به دلیل فاصله کم آن از شهر شیراز و مجاورت آن با تعداد زیادی روستا و نیز به دلیل استفاده از نمک دریاچه در صنایع مختلف دارای اهمیت ویژه ای است. با بکارگیری فنون سنجش از دور چند طیفی می-توان درمدت زمانی کوتاه و با کمترین هزینه و نیروی کار به اطلاعات مفیدی در زمینه زمین شیمی دریاچه ها به ویژه...
THE GAP BETWEEN CLINICAL PRACTICE and scientific discovery, often referred to as the gap between the bench and the bedside, is a huge void in some disease processes. Translational research is often focused on bridging that gap. Acute lung injury (ALI) is an excellent example of how critical that bridging can be. ALI presents unique challenges to clinicians and scientists. On the clinical side, ...
This study was designed to test the hypothesis that whether the plasma level of advanced oxidant protein products (AOPPs) would be useful for the clinical diagnosis of acute lung injury (ALI) following cardiac surgery with the technique of cardiopulmonary bypass (CPB). In this prospective study, seventy consecutive adults undergoing open heart surgery with CPB were included and assigned into th...
In vitro exposure to aerosols at the air-liquid interface (ALI) preserves the physical and chemical characteristics of aerosol particles. Although frequently described as being a more physiologic exposure method, ALI exposure has not been directly compared with conventional in vitro exposures where the particles are suspended in medium. We exposed immortalized human bronchial epithelial cells (...
Acetaminophen (APAP) overdoses are of major clinical concern. Growing evidence underlines a pathogenic contribution of sterile postinjury inflammation in APAP-induced acute liver injury (APAP-ALI) and justifies development of anti-inflammatory therapies with therapeutic efficacy beyond the therapeutic window of the only current treatment option, N-acetylcysteine (NAC). The inflammatory mediator...
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