The circulating apoptosis inhibitor of macrophage (AIM) protein performs differential preventive roles against liver steatosis and hepatocellular carcinoma (HCC) development. Since non-alcoholic fatty liver disease, which is known as a manifestation of metabolic syndrome, has been increasingly highlighted for its association with HCC, therapeutic application of AIM would open the door toward a ...

Silymarin has long been used as a hepatoprotective remedy. Chronic toxicity studies in rodents have confirmed that silymarin has a very low toxicity. These data support its history as a safe medication in hepatic diseases. In the last years, several studies expanded our understanding of the pharmacology of silymarin and its molecular mechanisms of action. These new insights may affect the handl...

The authors summarize and update the most recent knowledge in the field of prevalence, natural history and incidence of Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic Steatohepatitis (NASH). These novel diseases, firstly recognized at the beginning of the second millennium, arose suddenly to the attention of the clinicians, because they are the hepatic expression of the "so-called"...

The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology NAGA CHALASANI, MD, FACG,* ZOBAIR YOUNOSSI, MD, FACG, JOEL E. LAVINE, MD, PhD, ANNA MAE DIEHL, MD, ELIZABETH M. BRUNT, MD, KENNETH CUSI, MD, MICHAEL CHARLTON, MD,** an...

Metabolic syndrome is a cluster of several clinical conditions characterized by insulin-resistance and high cardiovascular risk. Non-alcoholic fatty liver disease is the liver expression of the metabolic syndrome, and insulin resistance can be a frequent comorbidity in several chronic liver diseases, in particular hepatitis C virus infection and/or cirrhosis. Several studies have demonstrated t...

Excessive ingestion of alcohol is one of the major causes of chronic liver disease worldwide. Alcoholic liver disease (ALD) encompasses a broad spectrum of diseases ranging from steatosis (fatty liver), steatohepatitis, fibrosis, cirrhosis to hepatocarcinoma. Almost all heavy drinkers develop fatty liver; however, only up to 30% of heavy drinkers may develop more several forms of chronic liver ...

The prevalence of alcoholic liver disease and non-alcoholic patients has nearly doubled over the past decades worldwide. Alcoholic among with chronic increased arisen due to alcohol consumption obesity. diagnosis plays a crucial role in treating such conditions based on stages functioning. elevated enzymes are key characterizing identifying (ALD) NAFLD. Later on, there is progression by develop...

TLRs (Toll-like receptors), as evolutionarily conserved germline-encoded pattern recognition receptors, have a crucial role in early host defence by recognizing so-called PAMPs (pathogen-associated molecular patterns) and may serve as an important link between innate and adaptive immunity. In the liver, TLRs play an important role in the wound healing and regeneration processes, but they are al...

Scientific review covers current data regarding the role of quercetin in therapeutic corrections various liver diseases, particular non-alcoholic fatty disease, chronic hepatitis, drug-induced disease. The aim was to sum up scientific properties, its mechanism action and possibilities this flavonoid treatment diseases.Conclusions. Quercetin is found possess antioxidant, anti-inflammatory, hypol...