Although heavy alcohol intake is known to be one of the most common causative factors of liver disease, pancreatitis, upper gastrointestinal and neurological disorders, the influence of the drinking pattern is largely unknown. The study investigated the relationship of alcohol-related medical disorders in alcoholics and their drinking pattern. Two hundred and forty-one chronic alcoholics were r...

Repeated alcohol withdrawal has been shown to kindle seizure activity. The purpose of the present investigation was to study electrical amygdala kindling in rats previously exposed to alcohol-withdrawal kindling. In three independent experiments, male Wistar rats were subjected to multiple episodes each consisting of 2 days of severe alcohol intoxication and 5 days of alcohol withdrawal. In the...

N Engl J Med 2003;348:1786-95. Copyright © 2003 Massachusetts Medical Society. ach year in the united states, approximately 8.2 million persons are dependent on alcohol and 3.5 million are dependent on illicit drugs, including stimulants (1 million) and heroin (750,000). 1 In a sample from primary care practice, 15 percent of patients had either an “at-risk” pattern of alcohol use or an alcohol...

The purpose of this study was to determine if aversive effects of alcohol withdrawal could be detected in mice using the place conditioning procedure and whether the GABA(A) receptor antagonist, pentylenetetrazol (PTZ), would increase the aversive effects of alcohol withdrawal and increase the probability of detecting conditioned place aversion. Subjects were alcohol-naïve mice from a specific ...

N Engl J Med 2003;348:1786-95. Copyright © 2003 Massachusetts Medical Society. ach year in the united states, approximately 8.2 million persons are dependent on alcohol and 3.5 million are dependent on illicit drugs, including stimulants (1 million) and heroin (750,000). 1 In a sample from primary care practice, 15 percent of patients had either an “at-risk” pattern of alcohol use or an alcohol...

TOPIC: Cardiovascular Disease TYPE: Medical Student/Resident Case Reports INTRODUCTION: Delirium tremens is characterized by a sympathetic overdrive after acute alcohol reduction. In chronic users, this catecholamine surge especially dangerous due to the long-standing perivascular cell damage in microvasculature of heart [1]. Furthermore, coronary muscle bridges increase arterial wall tension, ...

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BACKGROUND Delirium is an urgent condition in psychiatry and it occurs after long-lasting alcohol abuse, in surgical procedures and other organic mental syndromes with deprivation of interpersonal and social stimulations. The aim was to evaluate of sociodemographical and psychopathological differences in delirium patients with alcoholand surgical genesis, studied in period from January 1(st) 20...