OBJECTIVES Surgical correction of skeletal maxillary retroposition is often associated with changes in the morphology of the nose. Unwanted alar flaring of the nose is observed in many cases. The aim of the present study was therefore to investigate the influence of surgical advancement of the maxilla on changes in the soft-tissue morphology of the nose. Having a coefficient that allows predict...

Pax7 is a member of the highly conserved Pax gene family that is expressed in restricted zones of the central nervous system (CNS) during development, being involved in early brain regionalization and the maintenance of the regional identity. Using sensitive immunohistochemical techniques we have analyzed the spatiotemporal pattern of Pax7 expression in the brain of the anuran amphibian Xenopus...

OBJECTIVE To evaluate the aesthetic and functional outcomes of a full-thickness skin graft and a separately harvested auricular cartilage graft for nasal alar defects created by Mohs micrographic surgery. DESIGN Twenty patients with deep Mohs micrographic surgery defects of the nasal ala who underwent reconstruction with a full-thickness skin graft and an auricular cartilage graft were prospe...

Plant growth retardants Alar (dimethylhydrazide of succinic acid) and its structural analogue MEIA (β-monomethyl ester of itaconic acid) at a concentration 2000mg/l sprayed at the fourth true leaf stage of tobacco seedlings caused identical retardation in stem growth from the second till the tenth day after treatment. Soluble peroxidase activity in stems of the treated plants increased on the s...

OBJECTIVE To determine the usefulness of a triple-flap technique for repair of large zone 2 Mohs defects of the nose. METHODS The triple-flap technique was performed on 10 fresh adult cadaver heads that had been injected intravascularly with blue dye. Two distances were measured and recorded: (1) the distance from the most lateral portion of the alar crease to the transverse facial artery; an...

The Olig3 gene encodes a bHLH factor that is expressed in the ventricular zone of the dorsal alar plate of the hindbrain. We found that the Olig3(+) progenitor domain encompassed subdomains that co-expressed Math1, Ngn1, Mash1 and Ptf1a. Olig3(+) cells give rise to neuronal types in the dorsal alar plate that we denote as class A neurons. We used genetic lineage tracing to demonstrate that clas...

PURPOSE Asymmetric nostrils that develop after rhinoplasty may result in nasal tip deformity and result in patient dissatisfaction. No systemic study on methods for the correction of transformed nostrils has been reported. In the current study, asymmetric nostrils were classified according to the degree of asymmetry and the authors' experiences on the correction of nostril deformities are descr...

Nasal tip surgery has become significantly more complex since the introduction of tip grafting and the many suture designs that followed the resurgence of open rhinoplasty. Independent of the surgeon's technical approach, however, is the need to identify the critical anatomical characteristics that will make nasal tip surgery successful. It is the author's contention that only two such features...

background the ala of the nose, with its particular texture and characteristics, poses both aesthetically and functionally intriguing challenges and is rather problematic regarding choices for reconstructive methods. both flaps and grafts have been used to restore natural structure of nasal ala. the present study summarizes a ten-year experience of reconstructive surgery using small composite g...

Many of the genes involved in brain patterning during development are highly conserved in vertebrates and similarities in their expression patterns help to recognize homologous cell types or brain regions. Among these genes, Pax6 and Pax7 are expressed in regionally restricted patterns in the brain and are essential for its development. In the present immunohistochemical study we analyzed the d...