Effect of in-water oxygen prebreathing at different depths on decompression-induced bubble formation and platelet activation in scuba divers was evaluated. Six volunteers participated in four diving protocols, with 2 wk of recovery between dives. On dive 1, before diving, all divers breathed normally for 20 min at the surface of the sea (Air). On dive 2, before diving, all divers breathed 100% ...

Normobaric hyperoxia (NBO) has been shown to be neuro- and vaso-protective during ischemic stroke. However, the underlying mechanisms remain to be fully elucidated. Activation of NADPH oxidase critically contributes to ischemic brain damage via increase in ROS production. We herein tested the hypothesis that NBO protects the blood-brain barrier (BBB) via inhibiting gp91phox (or called Nox2) con...

The structural aspects of xCs2O-(1-x)B2O3 glasses have been investigated by molecular dynamics as functions of Cs2O content (x=0.2, 0.3, and 0.4) and temperature (T=300 and 1250 K). The tetrahedral (BØ4-) and triangular (BØ3,BØ2O-, and BØO2 (2-)) short-range order borate units were found to be the structure-building entities of the simulated glasses [Ø=bridging oxygen (BO) and O-=nonbridging ox...

Normobaric hyperoxia (NBO) and cilostazol (6-[4-(1-cyclohexy-1H-tetrazol-5-yl)butoxyl]-3,4-dihydro-2-(1H)-quinolinone) (a selective inhibitor of phosphodiesterase 3) have each been reported to exert neuroprotective effects against acute brain injury after cerebral ischemia in rodents. Here, we evaluated the potential neuroprotective effects of combination treatment with NBO and cilostazol again...

First principles electronic structure calculations are typically performed in terms of molecular orbitals (or bands), providing a straightforward theoretical avenue for approximations of increasing sophistication, but do not usually provide any qualitative chemical information about the system. We can derive such information via post-processing using natural bond orbital (NBO) analysis, which p...

The presence of a salvageable penumbra, a region of ischemic brain tissue with sufficient energy for short-term survival, has been widely agreed as the premise for thrombolytic therapy with tissue plasminogen activator (tPA), which remains the only United States Food and Drug Administration (FDA) approved treatment for acute ischemia stroke. However, the use of tPA has been profoundly constrain...

Density function M06 method has been used to optimize the geometries of shikonin -thymine at 6-311++G** basis. Finally, fourteen stabilized complexes have been obtained. Theories of atoms in molecules (AIM) and natural bond orbital (NBO) have been utilized to investigate the hydrogen bonds involved in all the systems. The interaction energies of all the complexes were corrected by basis set sup...

Oxygen therapy (OT) with hyperbaric oxygen (HBO) or normobaric hyperoxia (NBO) improves the oxygenation of penumbral tissue in experimental ischemic stroke. However, whether this results in the improvement of energy metabolism is unclear. We investigated the effect of both OTs on tissue acidosis and on ATP production. Beginning 25 min after filament middle cerebral artery occlusion (MCAO), mice...

We analysed RXTE data of Sco X-1 which show kHz quasi-periodic oscillations (QPOs) and the ∼6–8 Hz normal-branch oscillation (NBO) simultaneously. Using power spectra of 0.03–0.5 s data segments, we find that both the upper kHz QPO frequency ν2 and the ratio of lower to upper kHz QPO amplitude are anticorrelated to variations in the X-ray count-rate taking place on the NBO time scale. The frequ...

Beryllium difluoride BeF2 reacts with liquid ammonia forming discrete diammine difluoro beryllium(II) [BeF2(NH3)2] molecules. The colorless compound crystallizes in the monoclinic space group P21/c with a = 4.8815(2), b = 6.8528(3), c = 10.3690(5) Å, β = 92.01(1)◦ , V = 346.65(3) Å3 at 123 K with Z = 4. [BeF2(NH3)2] is the first structurally characterized example of a berylliumammonia complex. ...