OBJECTIVE To evaluate the variations in the detection of Porphyromonas gingivalis and/or Aggregatibacter actinomycetemcomitans before and after systemic administration of amoxicillin plus metronidazole in association with non-surgical periodontal therapy (NSPT). BACKGROUND The adjunctive use of antibiotics has been advocated to improve the clinical outcomes of NSPT. However, no systematic rev...

Exopolysaccharides have a diverse set of functions in most bacteria including a mechanistic role in protecting bacteria against environmental stresses. Among the many functions attributed to the exopolysaccharides, biofilm formation, antibiotic resistance, immune evasion and colonization have been studied most extensively. The exopolysaccharide produced by many Gram positive as well as Gram neg...

Abundant Secretion of Bioactive Interleukin-1 by Human Macrophages Induced by Actinobacillus actinomycetemcomitans Leukotoxin P. Kelk, R. Claesson, L. Hänström, U. H. Lerner, S. Kalfas, and A. Johansson* Divisions of Periodontology, Oral Microbiology, and Oral Cell Biology, Department of Odontology, Faculty of Medicine, Umeå University, Umeå, Sweden, and School of Dentistry, Aristotle Universit...

Three tetracyclines (tetracycline, doxycycline, and minocycline) were found to possess iron-chelating activity in a colorimetric siderophore assay. Determination of MICs indicated that the activity of doxycycline against the periodontopathogen Actinobacillus actinomycetemcomitans was only slightly influenced by the presence of an excess of iron that likely saturates the antibiotic. On the other...

The stability of hemolytic activity, antibiotic resistance and plasmid detection in Actinobacillus actinomycetemcomitans isolates were studied. These characteristics were stable for all experimental conditions. All tested isolates lost or changed some phenotypic characteristics such as colonial morphology and growth in liquid medium.

This longitudinal study evaluated the response to periodontal treatment by subjects infected with either JP2 (n = 25) or non-JP2 (n = 25) Aggregatibacter (Actinobacillus) actinomycetemcomitans. Participants were treated during the first 4 months by receiving (i) scaling and root planing, (ii) systemic antibiotic therapy, and (iii) periodontal surgery. Probing depth (PD), clinical attachment lev...

The aim of the present study was to evaluate the presence of the periodontal pathogens that form the red complex (Tannerella forsythia, Porphyromonas gingivalis and Treponema denticola) and Aggregatibacter actinomycetemcomitans in patients with chronic periodontitis. The sample consisted of 29 patients with a clinical and radiographic diagnosis of chronic periodontitis based on the criteria of ...