OBJECTIVES Biological modelling of routinely collected newborn screening data has emerged as a novel method for deriving postnatal gestational age estimates. Validation of published models has previously been limited to cohorts largely consisting of infants of white Caucasian ethnicity. In this study, we sought to determine the validity of a published gestational age estimation algorithm among ...

Patients: Patients ≥ 30 years of age (derivation group, n = 33 268, median age 52 y, 62% men; validation group, n = 5821, median age 55 y, 55% men) with normal ECGs and suspected CAD referred for symptom-limited exercise treadmill testing. Exclusion criteria were coronary disease, heart failure, left ventricular systolic dysfunction, cardiomyopathy, valvular or congenital heart disease, past re...

Background. The differential diagnoses of acute appendicitis obstetrics, and gynecological conditions (OB-GYNc) or nonspecific abdominal pain in young adult females with lower abdominal pain are clinically challenging. The present study aimed to validate the recently developed clinical score for the diagnosis of acute lower abdominal pain in female of reproductive age. Method. Medical records o...

PURPOSE To create a risk model for neovascular age-related macular degeneration (nAMD) based on nongenetic factors. METHODS In this case-control study, 1459 individuals were included, 445 patients showed nAMD and 1014 were healthy controls. Participants were randomly assigned into a training set (containing two-thirds of individuals) and a validation set. Stepwise logistic regression analysis...

OBJECTIVES To develop and validate a clinical risk score to identify patients at risk of chronic obstructive pulmonary disease (COPD) using clinical factors routinely recorded in primary care. DESIGN Case-control study of patients containing one incident COPD case to two controls matched on age, sex and general practice. Candidate risk factors were included in a conditional logistic regressio...