نتایج جستجو برای: age 2327 201

تعداد نتایج: 766279  

2015
Anu-Maarit Moilanen Reetta Riikonen Riikka Oksala Laura Ravanti Eija Aho Gerd Wohlfahrt Pirjo S. Nykänen Olli P. Törmäkangas Jorma J. Palvimo Pekka J. Kallio

Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and several mechanisms have been proposed to explain the addiction. Known causes of CRPC include gene amplification and overexpression as well as point mutations of AR. We report here the pharmacological profile of ODM-201, a nov...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Khandaker Siddiquee Shumin Zhang Wayne C Guida Michelle A Blaskovich Benjamin Greedy Harshani R Lawrence M L Richard Yip Richard Jove Mark M McLaughlin Nicholas J Lawrence Said M Sebti James Turkson

S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using structure-based virtual screening with a computer model of the Stat3 SH2 domain bound to its Stat3 phosphotyrosine peptide derived from the x-ray crystal structure of the Stat3beta homodimer. S3I-201 inhibits Stat3.Stat3 complex formation and S...

Journal: :Protein expression and purification 2015
Kittikhun Wangkanont Katrina T Forest Laura L Kiessling

The roles of the extracellular domain of type II TGF-β receptor (TBRII-ECD) in physiological processes ranging from development to cancer to wound healing render it an attractive target for exploration with chemical tools. For such applications, large amounts of active soluble protein are needed, but the yields of TBRII-ECD we obtained with current folding protocols were variable. To expedite t...

Journal: :Hellenic journal of nuclear medicine 2006
Babak Fallahi Davood Beiki Majid Assadi Armaghan Fard Esfahani

Thallium-201 chloride ((201)TlCl) is frequently used for imaging of a variety of malignant tumors viz., thyroid, lung, brain, bone and breast, however in patients with colorectal cancer, its role is not well established. In this case report we present three patients with colorectal cancer recurrence, with inconclusive computed tomography (CT) findings while (201)TlCl single photon emission tomo...

Journal: :Journal of radiology case reports 2009
Yasuyo Tonomura Hiroshi Kataoka Mari Terashima Takayuki Shinkai Satoshi Ueno

We describe the usefulness of thallium-201 SPECT in a patient with neoplastic meningitis (NM) from gastric carcinoma. Thallium-201 SPECT is of value for the diagnosis of cancer; retention of thallium-201 on delayed images strongly suggests malignancy. NM is a lethal, major neurologic complication of cancer. The standard for the diagnosis of NM is cytologic confirmation of malignant cells in CSF...

Journal: :American journal of physiology. Heart and circulatory physiology 2006
Isaac George Geng-Hua Yi Allison R Schulman Brad T Morrow Yanping Cheng Anguo Gu Geping Zhang Mehmet C Oz Daniel Burkhoff Jie Wang

The purpose of this study was to test if HBOC-201, a hemoglobin-based oxygen-carrying solution, can decrease infarct size (or Inf) during acute, severe myocardial ischemia and reperfusion. To test the impact of HBOC-201 on infarct size, ischemia was produced in 18 dogs by coronary stenosis to achieve 80-95% flow reduction for 195 min along with pacing 10% above the spontaneous heart rate, follo...

Journal: :European urology 2016
Christophe Massard Heidi M Penttinen Egils Vjaters Petri Bono Vilnis Lietuvietis Teuvo L Tammela Annamari Vuorela Pirjo Nykänen Pasi Pohjanjousi Amir Snapir Karim Fizazi

BACKGROUND ODM-201 is a novel second-generation androgen receptor inhibitor for the treatment of metastatic castration-resistant prostate cancer (mCRPC). OBJECTIVE To evaluate the pharmacokinetics of ODM-201 tablet products and preliminary long-term safety, tolerability, and antitumor activity of ODM-201 in chemotherapy-naive men with mCRPC. DESIGN, SETTING, AND PARTICIPANTS Thirty patients...

Journal: :Circulation 1975
H W Strauss K Harrison J K Langan E Lebowitz B Pitt

Following intravenous administration, the myocardial concentration of tracer thallium-201, potassium-43, and rubidium-81 were determined in mice; thallium was present in the greatest concentration in the myocardium (2.08% compared 1.25% for potassium and 1.15% for rubidium at 10 minutes). The regional myocardial distribution of thallium-201 was determined in dogs under conditions of normal flow...

2005
IAN K. BAILEY H. WILLIAM STRAUSS BERTRAM PITT

The sensitivity of myocardial perfusion imaging (MPI) using thallium-201 injected both at rest and during peak exercise was compared to simultaneously recorded 12 lead electrocardiography (ECG) for the detection of transient ischemia in 20 normal subjects and 63 patients with coronary artery disease (CAD). No significant perfusion defects or ECG changes were seen on either the rest or exercise ...

Journal: :Singapore medical journal 2004
Y H Chan

Correspondence to: Dr Y H Chan Tel: (65) 6325 7070 Fax: (65) 6324 2700 Email: chanyh@ cteru.com.sg In the 100 series(1-4) the common univariate techniques (summarized in Table I) available for data analyses were discussed. These techniques do not allow us to take into account the effect of other covariates/ confounders (except for partial correlation(4)) in an analysis. In such situations, a Re...

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