Objective: The aim of this study was to investigate the potential a liquisolid system improve dissolution rate and bioavailability nebivolol hydrochloride. Methods: Solubility determined in different nonvolatile solvents finalize best vehicle having maximum solubility. compacts were prepared using Fujicalin as carrier material, Aerosil 200 coating Polyethylene glycol 400 liquid vehicle, Croscar...

The viscous flow behavior of a 12.5 vol% hydrophobic fumed silica (Aerosil® R816) suspension in polypropylene glycol low molecular weight (PPG400) was studied stress-controlled rheometer. steady curve showed shear thickening between two thinning regions. Time-dependent viscosity response provoked by step changes stresses corresponding to the shear-thickening region apparently agrees with thixot...

In the present study an attempt was made to formulate and evaluate Calcium and Vitamin K3 tablet using wet granulation technique incorporating various Excipients like Starch Powder, Starch Paste, Magnesium Sterate, Aerosil, Talc, Lactose, Vitamin K Liquid form and Water. The Formulated tablets were evaluated for different physicochemical properties like rheological properties, weight variation,...

The main components for tablet formulations are the fillers, binders, crushers, thinners and lubricants. Among these components, binders play a key role on powder cohesion properties during formation of granules. In this study, turmeric extract tablets were formulated using 15 g extract, 35 aerosil, 12.8 lactose, 1% magnesium stearate, 200 ml aquadest gelatin as binder. To evaluate effect formu...

Myosin light-chain kinase (MLCK) of smooth muscle is multifunctional, being composed of N-terminal actin-binding domain, central kinase domain, and C-terminal myosin-binding domain. The kinase domain is the best characterized; this domain activates the interaction of smooth-muscle myosin with actin by phosphorylating the myosin light chain. We have recently shown that the Met-1-Pro-41 sequence ...

Obesity is associated with insulin resistance and other major cardiovascular risk factors. A common amino acid polymorphism at codon 972 of the insulin receptor substrate-1 (IRS-1) has been shown to interact with obesity in the expression of insulin resistance. The plasma concentration of the adipocyte-specific hormone leptin is increased in obesity and is correlated with adipose tissue mass. B...

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