Background Many aeroallergens activate PAR-2 receptors on the airway epithelium. We have shown that PAR-2 activation participates in allergic sensitization and allergic airway inflammation in animal models of asthma. Moreover, PAR-2 is upregulated on the airway epithelium of asthmatics, but the mechanisms and factors responsible are unknown. As asthmatic airways are under various types of physi...

Background Subcutaneous immunotherapy (SIT) injections for aeroallergens are often utilized in patients. SIT should be injected into the subcutaneous space in the mid-posterolateral upper arm. If the injections are given intramuscularly (IM), there may be an increased risk of anaphylaxis. In our allergy clinic, SIT is given with BD Safety GlideTM Allergy syringes with needle length 13mm. There ...

few biomarkers that can predict the clinical response to allergen immunotherapy (ait) have been identified. the aim of the present study was to investigate parameters that could be used “in predicting the clinical response to ait” in children with asthma caused by house dust mites. we evaluated 107 children with mild persistent asthma who were sensitised only to mite aeroallergens. the study gr...

Climate change has the potential to have many significant impacts on aeroallergens such as pollen and mould spores, and therefore related diseases such as asthma and allergic rhinitis. This paper critically reviews this topic, with a focus on the potential adaptation measures that have been identified to date. These are aeroallergen monitoring; aeroallergen forecasting; allergenic plant managem...

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is more common in women than in men. Conclusions: Approximately 25 chemicals appear to be responsible for as many as one half of all cases of allergic contact dermatitis. These include nickel, preservatives, dyes, and fragrances. in this study Allergic contact dermatitis is more common in women than in men. This predominantly is a result of allergy to nickel, which is much more common in women ...

Background Coexistence of food hypersensitivity are frequently observed in patients with allergy to plant and animals. Principal method of cure of aeroallergens hypersensitivity is specific allergy immunotherapy (SIT). Effectiveness of this therapy is assessed based on clinical symptoms abated. Sometimes we observed less effect this method of treatment in some patients, probably connected with ...

Background In natural history of allergy, in some patients sensitized to aeroallergens, appear allergy to novel allergens, and in some cases this are food allergens. Subcutaneous immunotherapy (SIT) is the method of treatment patient with pollen allergy, and one of the aim of this treatment is protection against development novel allergy, but sometimes in clinical practice we observed hypersens...