Objectives: To assess adverse drug reactions (ADRs) reporting and identify factors to improve ADR among community pharmacists in the Greater Accra Region of Ghana.Design: A quantitative cross-sectional study.Setting: Community pharmacies Ghana.Participants: We randomly selected 210 from a list Accra, Ghana. All participants had been practicing past one year, with this study being conducted June...

Although many reports have described the incidence of adverse drug reactions, none have explained their variable severity or why they happen. Because human physiology shares many of the features of other complex adaptive systems, reactions to drug therapy were examined mathematically for specific patterns to show (1) that the severity of adverse drug reactions follows a distribution seen in oth...

Adverse drug reaction and drug interactions represent negative consequences of pharmacotherapy. A thorough knowledge of how the adverse reactions and drug interactions occur will aid in our ability to provide the best patient care possible. Adverse drug reactions and drug interactions are defined and mechanisms of their occurrence are discussed; ways to identify, assess, manage, and report thes...

OBJECTIVE To identify gaps in the systems for reporting adverse events following immunization (AEFI) in Europe by means of an interactive database constructed using a standardized approach. METHODS A comparative survey was conducted in 1999-2000, using structured questionnaires addressed to the government authorities responsible for national immunization programmes and drug safety surveillanc...

Background: Cutaneous drug reaction seems to be relatively common The aim of the study was to recognize offending drugs, evaluate patients' characteristics and educate the patients to avoid selfadministration and re-administration of drugs. Methods: We retrospectively and prospectively analyzed data from Sina hospital in Tabriz (2000-2005) to determine the number of hospitalizations and visits ...

Post-marketing surveillance systems rely on spontaneous reporting databases maintained by health regulators to identify safety issues arising from medicines once they are marketed. Quantitative safety signal detection methods such as Proportional Reporting ratio (PRR), Reporting Odds Ratio (ROR), Bayesian Confidence Propagation Neural Network (BCPNN), and empirical Bayesian technique are applie...

INTRODUCTION Adult Still Disease (ASD) is a rare (incidence 1-1,6/1,000,000 in Europe) seronegative polyarthropathy diagnosed with clinical criteria, excluding other etiologies. Minocycline, a semisynthetic derivative of tetracycline, has been associated with many adverse effects. We present the case of a 18-years-old man with a high suspicion of an adverse drug reaction (ADR), that was finally...