the monitoring and reporting of adverse drug reactions (adrs) in hospitals aims to identify and quantify the risks associated with the use of drugs. the present study was performed to characterize the rate and the pattern of adrs, due to cardiovascular drugs and anticoagulants, in a tertiary care teaching hospital. for this purpose, all the patients treated with cardiovascular drugs and anticoa...

Cytochrome P450 is a family of isozymes responsible for the biotransformation of several drugs. Drug metabolism via the cytochrome P450 system has emerged as an important determinant in the occurrence of several drug interactions that can result in drug toxicities, reduced pharmacological effect, and adverse drug reactions. Recognizing whether the drugs involved act as enzyme substrates, induce...

interferon (ifn)-based therapy, the cornerstone for treatment of hepatitis c virus (hcv) infection, is generally considered to be the single most effective treatment strategy for this infection. although most adverse effects of ifn therapy respond very well to the cessation of this drug, there are reports of serious irreversible adverse effects. this review article evaluates the adverse effects...

An important complication of chemotherapy is thromboembolic events that can occur during treatment course. In this way, Warfarin can be used as an efficient prophylactic agent to prevent these complications. Although bleeding is a common adverse effect of Warfarin, eosinophilia is a rare side effect of this drug. We have reported a 5-year-old boy with Burkitt lymphoma who underwent chemotherapy...

In this paper, we present preliminary results obtained using a system based on cooccurrence of drug-effect pairs as a first step in the study of detecting adverse drug reactions and drug indications from social media texts. To the best of our knowledge, this is the first work that extracts this kind of relationships from user messages that were collected from an online Spanish health-forum. In ...