The reaction between reducing sugars and protein free amines, known as the Maillar reaction results in the formation of advanced glycation endproducts (AGEs). AGE modification changes the structure of proteins to amyloid cross-beta structure. These protein structures can activate receptors known as RAGE on glial cells (microglia and astrocytes), and induce the expression of inducible nitric oxi...

OBJECTIVES To evaluate clinical outcomes of pregnancies in adolescent, advanced and reproductive women maternal age. MATERIALS AND METHODS A total of 187 pregnant women were included into the study 51 (27.27%) were adolescent pregnancies, mean age 17.7 +/- 3.3 years (range, 14-18 years), 40 (21.29%) advanced maternal age pregnancies, mean age 41.4 +/- 2.6 years (range, 39-50 years) and 96 (51...

BACKGROUND The trend to delay motherhood to the age of 30 and beyond is established in most high-income countries but relatively little is known about potential effects on maternal emotional well-being. This study investigates satisfaction with life during pregnancy and the first three years of motherhood in women expecting their first baby at an advanced and very advanced age. METHODS The st...

abstract background: for infertile women aged over 35 years, failure of the zp (zona pellucida) to rupture is believed to be associated with a decreased implantation rate in in vitro fertilization (ivf) or intra cytoplasmic sperm injection (icsi). objective: in this research, laser assisted hatching (lah) was offered to patients with advanced maternal age to evaluate a possible benefit. materia...