Objective To investigate the predictors of hypophosphatemic osteomalacia induced by adefovir dipivoxil (ADV) and to monitor for early detection. Patients and methods Hospitalized patients who were diagnosed with ADV-related hypo-phosphatemic osteomalacia were recruited and retrospectively analyzed in our hospital from January 2012 to December 2016. A telephone interview was conducted at 1, 3,...

BACKGROUND Gene therapy has been utilized to achieve posterior intertransverse process fusion in rodents. To our knowledge, however, no one has previously reported on the use of this technique to achieve anterior spinal fusion in mammals. The purpose of the present study was to determine if a gene-therapy technique can be utilized to achieve anterior intradiscal fusion in pigs with use of minim...

We present a new routing algorithm called Adaptive Distance Vector (ADV) for mobile, ad hoc networks (MANETs). ADV is a distance vector routing algorithm that exhibits some on-demand characteristics by varying the frequency and the size of the routing updates in response to the network load and mobility conditions. Using simulations we show that ADV outperforms AODV and DSR especially in high m...

Abstract: Adenoviruses (ADV) often cause respiratory infections. They have, in contrast to other respiratory viruses via a potential acute phase parameter (C-reactive protein, leukocytes and interleukin 6) to trigger. ADV infections are associated with increased secretion of IL-6 and TNF-?lpha, which activates the synthesis of acute phase proteins. The exact pathogenic mechanism is still unclea...

Zingg, 11. H., Rozen, F., Breton, C., Larcher, A., Neculcea, J., Chu, K., Russo, C. and Arslan, A. (1995) Adv. Exp. Med. Biol. 395, 395-404 Bale, T. L., Pedersen, C. A. and Dorsa, D. M. (1995) Adv. Exp. Med. Biol. 395, 269-280 Ostrowski, N. L. and Lolait, S. J. (1995) Adv. Exp. Med. Biol. 395, 329-340 Flint, A. P. F., Lamming, G. E., Stewart, H. J. and Abayasekara, D. R. E. (1994) Philos. Trans...

DNA tumorviruses like adenoviruses (AdV) or human papillomaviruses (HPV) have adopted various strategies to interfere with antiproliferative transforming growth factor-beta (TGF-beta) signalling. Here we report that the AdV E1A oncoprotein is sufficient to induce Smad7 expression, an inhibitor of TGF-beta signalling. E1A but not HPV oncoproteins activated the Smad7 promoter. A promoter proximal...

Twenty-one intussusception (IS)-associated and 59 temporally linked adenoviral isolates from clinical infections were compared. Species C (15/21 IS- and 32/59 non-IS-associated isolates) dominated. Of these, serotype 2 (AdV-2) (7/15 IS-associated isolates) and serotype 1 (AdV-1) (16/32 non-IS-associated isolates) were the most commonly identified serotypes. DNA restriction analysis of AdV-2 iso...

Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus replication but exhibits nephrotoxicity when administered at a low dosage. We report two cases of Fanconi syndrome induced by ADV at 10 mg/day to call for regular ...

Neonatal mink kits infected with Aleutian mink disease parvovirus (ADV) develop an acute interstitial pneumonia with clinical symptoms and pathological lesions that resemble those seen in preterm human infants with respiratory distress syndrome and in human adults with adult respiratory distress syndrome. We have previously suggested that ADV replicates in the alveolar type II epithelial cells ...

BACKGROUND Adenoviruses contribute to morbidity and mortality among immunocompromised pediatric patients including stem cell and solid organ transplant recipients. Cidofovir (CDV), an antiviral compound approved by the FDA in 1996, is used for treatment of adenoviral (ADV) infections in immunocompromised patients despite concern of potential nephrotoxicity.   METHODS We conducted a retrospect...