: Rapidly expanding evidence increasingly strengthens the evidence linking psychological factors to asthma and allergy expression. Parallel studies in animals and humans demonstrating the influence of prenatal maternal stress and early caregiving experiences on the disrupted regulation of defensive biological systems [eg, sympathetic and adrenomedullary (SAM) system and the hypothalamicpituitar...

Aggressive behavior induces an adrenocortical stress response, and sudden stressors often precipitate violent behavior. Experiments in rats revealed a fast, mutual, positive feedback between the adrenocortical stress response and a brain mechanism controlling aggression. Stimulation of the aggressive area in the hypothalamus rapidly activated the adrenocortical response, even in the absence of ...

Free acid· fluorescent corticosteroids (11-0HCS) in plasma of patients with adrenocortical disorder was studied by the m ethod of De Moor. Differences in diurnal variations of 11-0HCS value were observed between healthy per s ons, pa tients with adenoma, and patients w ith hyperplasia of adr enals. Intravenous infus ion of cort icot ropin was efficient for the estimation of the adrenocortical f...

Background. Adrenocortical carcinomas represent rare malignancies. In cases of hormone-secreting tumors, the hormone in excess determines the nearly diagnostic clinical presentation. Biologically inert tumors are diagnosed either due to the mass effect or incidentally. The purpose of the present study was to present an extremely rare presentation pattern of adrenocortical carcinoma. Case Presen...

The present study has been to test the effect of hydrocortisone (HC) on the mitotic incidence in adrenocortical cells of organ-cultured rat adrenal explants during a 24-hour incubation with or without angiotensin II (ANG). It was shown that HC significantly decreased the mean mitotic activity rate (MMAR) of adrenocortical cells in organ culture. That decrease concerned all the three cortical zo...

^THOUGH it has been generally assumed that psychological forces influence adrenocortical activity, the number of published studies on this subject is limited. Many of these studies have been made on small animals where the extrapolation of results to man is at best controversial.' ~21> 3Ti 42 Investigations in man have been generally indecisive because of the inadequacy of methods used to asses...

Adrenocortical carcinoma is a rare neoplasm with a poor prognosis. Very important advances have been made in the identification of the genetic determinants of adrenocortical carcinoma pathogenesis but our understanding is still limited about the mechanisms that determine cancer spread and metastasis. One major problem hindering preclinical experimentation for new therapies for adrenocortical ca...

Nonclassical form of 21-hydroxylase deficiency (NC 21OHD) as a frequent variant on the milder end of the disease spectrum has been widely acknowledged, but its potential contribution to adrenocortical tumorigenesis has not been fully elucidated. We report a 66-year old male case of bilateral adrenocortical incidentaloma, associated with partial 21OHD without any episodes of hypoadrenocorticism ...

The hypertension occurring in association with adrenal cortical hyperfunction (Cushing's syndrome and congenital adrenal hyperplasia), the difficulty in establishing or maintaining experimental hypertension in the absence of the adrenal gland (1-3), and the amelioration of human "essential" hypertension by adrenalectomy (4) or the development of adrenal insufficiency (5) have led several invest...