Satellite RNA guides kinetochore assembly R ošić et al. reveal that a non-coding RNA transcribed from repetitive DNA sequences promotes kinetochore assembly and chromosome segregation during mitosis. Centromeres—the chromosome regions where kinetochore proteins assemble and attach chromosomes to the mitotic spindle—are defi ned by epige-netic factors such as the histone variant CENP-A rather th...

adrenal cortex is a tissue of excess in terms of both cholesterol metabolism and cholesterol exchange with the circulation. Exceptionally high levels of lipoprotein receptors in this highly vascularized tissue provide ready access to dietary cholesterol, allowing the adreno-cortical cells to maintain impressive stores of cytoplas-mic cholesterol ester (CE) droplets. Tightly packed among the CE ...

As stated in the introduction by R. A. Peters, the purpose of this issue of the British Medical Bulletin "is to present a cross section of the research now in progress in this field of membranes." Although the coverage of the field is by no means complete, this purpose is achieved reasonably well in a series of short and concise reviews by investigators who are actively working on the problems ...

(RMS) is among the most common extracranial solid tumors occurring in children 1. It is the commonest form of soft tissue sarcoma in children and young adults and accounts for approximately 4%-5% of all childhood malignancy with an annual incidence of 5.3 per million children under the age of 15 2. The peak incidence is seen early in childhood with a median age at diagnosis of about 5 years. Ma...

have described methods for the early establishment of an accurate prognosis in idiopathic facial palsy and for the reduction in the incidence of denervation, with permanent sequelae, in this common condition. The present communication describes our experience of the use of these two methods in the routine management of facial palsy in the two years following the controlled trials. The results s...

Mrs LG a 60-year-old woman was referred to the medical outpatient department by her general practitioner with a 2-month history of increased tiredness, lethargy and weight loss having lost approximately 2 stones in the preceding 5 months. She had been diagnosed with hypothyroidism a few years previously and had been on thyroxine intermittently. She was not on thyroxine when seen in clinic. Bloo...

T he long QT interval syndrome (LQTS) has a low incidence in the general population, but, like the Wolff-Parkinson-White (WPW) syndrome , it has a major impact. While the WPW syndrome is the Rosetta stone of reentry, the LQTS may be the Rosetta Stone for ventricular tachyar-rhythmias dependent on sympathetic stimulation. Present Study In a recent issue of Circulation, Schwartz et all provided f...

7-hydroxy-3-(4-hydroxyphenyl), C21H20C9] is a major active ingredient extracted from the traditional Chinese medicine Ge-gen (Radix Puerariae, RP). The uses of Ge-gen described in pharmacopoeias and in traditional systems of medicine are for the treatment of fever, pain, diabetes, measles, acute dysentery or diarrhea, etc. Puerarin has been shown to be able to block the beta adreno-receptor of ...

Patients with cervical carcinoma under radiotherapy have been fol lowed during and after radiotherapy for the incidence of chromosome aberrations in peripheral lymphocytes. In patients treated with adreno chrome monoguanylhydrazone methansulfonate (100 mg) before every irradiation the incidence was significantly lower than in those without the treatment. The result indicates chemical protection...

introduction broiler chickens are intensively selected for productive traits. the management of these highly productive animals must be optimal to allow their full genetic potential to be expressed. if this is not done, inefficient production and several metabolic diseases such as ascites become apparent. investigations in mammals indicated that the b- adrenoreceptor characteristics are differe...