The mammalian circadian timing system consists of a master pacemaker in the suprachiasmatic nucleus (SCN) and subordinate clocks that disseminate time information to various central and peripheral tissues. While the function of the SCN in circadian rhythm regulation has been extensively studied, we still have limited understanding of how peripheral tissue clock function contributes to the regul...

During fasting, activation of the counter-regulatory response (CRR) prevents hypoglycemia. A major effector arm is the autonomic nervous system that controls epinephrine release from adrenal chromaffin cells and, consequently, hepatic glucose production. However, whether modulation of autonomic function determines the relative strength of the CRR, and thus the ability to withstand food deprivat...

The adrenal hormones play a central role in response to environmental stimuli, both internal and external. We analyzed enzymes activities (LDHlactate dehydrogenase, GLDHglutamate dehydrogenase and AcPh – acid phosphatase) in adrenal cortex through swimming exercises and under the influence of B-group vitamins. The analyzed cases in the experiment revealed significant increase of enzyme activiti...

primary adrenal lymphoma is extremely rare. we report a case with primary bilateral adrenal lym-phoma in a young male patient. he presented with abdominal pain and weight loss. pathologic study revealed malignant lymphoma, diffuse large cell type (t- cell origin). patient recieved combination chemotherapy and radiation therapy but 22 months after diagnosis died because of progression of dis ease

Adrenal metastasis following gastrectomy for gastric cancer is often encountered as part of advanced systemic dissemination, which is usually unresectable. Thus, there are very few published case reports describing metastasectomy for adrenal metastasis from gastric cancer. Herein we present our experience in treating two patients diagnosed and treated for adrenal metastasis 6 years following in...

Pheochromocytoma (PC) is a tumor of chromaffin cells the sympathetic-adrenal system that produces large amount catecholamines (adrenaline, norepinephrine, dopamine). There are no reliable data in literature on frequency cardiac manifestations pheochromocytoma, which associated with rarity this pathology. This case demonstrates development catecholamine-induced cardiomyopathy, proceeding under g...

The hypothalamic-pituitary-adrenal axis is a dynamic system regulating glucocorticoid hormone synthesis in the adrenal glands. Many key factors within the adrenal steroidogenic pathway have been identified and studied, but little is known about how these factors function collectively as a dynamic network of interacting components. To investigate this, we developed a mathematical model of the ad...

testosterone enanthate (te) is used by many athletes as a muscle builder. previous studies showed that high concentration of the drug in plasma may affect the natural function of endocrine glands, specially the secretion of the adrenocortical hormones. the objective of the present study was to examine the effects of high concentration of te on histometrical structure of adrenal cortex in male r...

the prevalence of mental health disorders continues to rise worldwide, such that it is estimated that 1in 4 individuals will be affected by a mental health disorder at some point in their lifetime. research has found that the most prevalent mental health disorders are depressive disorder. depression is a common condition, particularly within the aging population. the development of depression, ...

BIOCHEMICAL DERANGEMENTS resulting from adrenal cortical hyperfunction or from critical reduction of the endogenous corticosteroid hormone supply are sometimes overshadowed by major disturbances of cardiovascular function. Arterial hypertension and congestive heart failure may be the predominanit presenting clinical features in patients with adrenal cortical hyperfunction. During acute illness ...