Obesity is described as the accumulation of excess body fat. Several health issues are caused by fat, including cancer, type 2 diabetes, and cardiovascular disease. Additionally, obesity rates among schoolchildren young adults rising globally, putting people at risk chronic diseases. Genetics, epigenetic modification, epigenomics, environmental factors influence inheritance patterns significant...

BACKGROUND Growing evidence suggests that the Arg16Arg genotype of the beta-2 adrenergic receptor gene may be associated with adverse effects of beta-agonist therapy. We sought to examine the association of beta-agonist use and the Arg16Gly polymorphism with lung function and mortality among participants in the Atherosclerosis Risk in Communities study. METHODOLOGY AND PRINCIPAL FINDINGS We g...

Asthma is common chronic inflammatory disease of the airways characterised by variable and attacks of cough and breathlesness, usually precipitated by an enviromental trigger (air pollution, smoke, etc). The prevalence and severity for allergic asthma have increased markedly in the last several decades. Dysregulated expression patterns of proand anti inflammatory mechanisms are thought to be re...

There is evidence of a hereditary component in chronic obstructive pulmonary disease (COPD). A number of genetic association studies have been performed to find susceptibility genes of COPD. The current authors performed a case-control, genetic-association study and a meta-analysis of 16 studies, involving seven polymorphisms in three well-studied genes: microsomal epoxide hydroxylase (EPHX1); ...

Objective: To explore the potential mechanism of Sini jia Renshen Decoction (SJRD) in treatment COVID-19 based on network pharmacology and molecular docking. Methods: The active compounds therapeutic targets SJRD were collected through Traditional Chinese Medicine Systems Pharmacology Database (TCMSP). Then a string database was used to build protein–protein interactions (PPI) between proteins,...