Partially purified samples of thymidine phosphorylase were obtained from four preparations of human uterine leiomyomas and uteri using the method of Yoshimura et al. (1990), Biochim. Biophys. Acta 1034, 107-113. Among the studied twelve pyrimidine derivatives, 5-bromouracil, 5-nitrouracil, 5-fluorouracil, 6-aminouracil, 4, 6-dihydroxy-5-nitropyrimidine are competitive inhibitors, while allyloxy...

OBJECTIVE In this study, we investigated the adverse effects of dietary zearalenone (ZEA) (0.5 to 1.5 mg/kg diet) on the localization and expression of the growth hormone receptor (GHR) in the uteri of post-weaning gilts and explored alternative mechanism of the reproductive toxicity of ZEA on piglets. METHODS A total of forty healthy piglets (Duroc×Landrace×Large White) aged 28 d were select...

Background and Objective: Uterus of rat with polycystic ovary (PCO) may show pathological features. We provided pathological evidence for the rat uterus with NO-induced PCO.    Materials and Methods: Wistar rats (weighing 200-250 g) were kept diestrous to receive L-arginine (50 mg/kg) intraperitoneally (i.p.) for 9 days/once a day. Control group solely received saline (1 ml/kg, 9 days/once per ...

One of the rare neoplasms of cervix uteri and vagina is clear cell carcinoma; mostly in patients with a positive past medical history of intrauterine diethylstilbestrol (DES) exposure which reveals the importance of other unknown risk factors of gynecologic neoplasms. 2 Asian women referred to the gynecology-oncology department. The first one came with a complaint of prolonged vaginal discharge...

Diethylstilbestrol (DES), a synthetic estrogen, was widely administered to pregnant women between 1947 and 1971 on account of a misconception that it could prevent miscarriages. The offspring of these women were diagnosed with various reproductive tract abnormalities, including cancer. We focused this study on DES-induced abnormalities in the uterus. We screened for altered DNA methylation patt...