Adiponectin protects the vascular system partly through stimulation of endothelial nitric oxide (NO) production and endothelium-dependent vasodilation. The present study investigated the role of the two recently identified adiponectin receptors (AdipoR1 and AdipoR2) and their downstream effectors in mediating the endothelium actions of adiponectin. In human umbilical vein endothelial cells (HUV...

BACKGROUND Individuals with non-alcohol fatty liver disease (NAFLD) exhibit impaired liver regeneration in a clinical setting and animal experiments. Adiponectin signaling is recognized as an important pathway of lipid metabolism, energy expenditure, anti-inflammation, and cellular proliferation. We herein investigate hepatic adiponectin signaling in dietary steatotic murine models undergoing h...

AIMS Despite recent advances in medical therapy, heart failure remains a leading cause for cardiovascular mortality, and its complex pathogenesis is incompletely understood. This study was performed to identify possible new therapeutic targets in dilated cardiomyopathy (DCM). METHODS AND RESULTS Oligonucleotide microarray analysis was performed on endomyocardial biopsies (EMBs) from patients ...

Objective: Total plasma adiponectin and high molecular weight (HMW) polymeric adiponectin are strongly positively correlated with insulin sensitivity. However we have recently reported paradoxical hyperadiponectinemia in patients with severe insulin resistance due to genetically defective insulin receptors. This implies either that the insulin receptor has a critical physiological role in contr...

Intrauterine growth restriction (IUGR) predisposes to obesity and adipose dysfunction. We previously demonstrated IUGR-induced increased visceral adipose deposition and dysregulated expression of peroxisome proliferator activated receptor- γ 2 (PPAR γ 2) in male adolescent rats, prior to the onset of obesity. In other studies, activation of PPAR γ increases subcutaneous adiponectin expression a...

Adiponectin is a multifunctional adipokine that has several oligomeric forms in the blood stream, which broadly regulates innate and acquired immunity. Therefore, in this study, we aimed to observe the differentiation of T helper (Th) cells and expression of costimulatory signaling molecules affected by adiponectin. The mRNA and protein expression levels of adiponectin and its receptors in oxid...

ADIPONECTIN IS ONE OF SEVERAL recently described, circulating, secretory products synthesized by adipose tissue and known collectively as “adipokines” and/or “adipocytokines” (7, 22). Adiponectin plays an important role in energy homeostasis, regulating both glucose and lipid metabolism (14, 26). Adiponectin exerts its metabolic effects by binding to two receptors: AdipoR1, which is ubiquitousl...

Adiponectin is an adipocyte derived hormone which acts in the CNS to control autonomic function, energy and cardiovascular homeostasis. Two 7-transmembrane domain receptors, AdipoR1 and AdipoR2, expressed in the hypothalamus and brainstem mediate the actions of adiponectin. The medulla's nucleus of the solitary tract (NTS) is the primary viscerosensory integration site and an important nucleus ...

background: the relationships between adiponectin and clinical outcomes in hemodialysis (hd) patients remain highly controversial. meanwhile, the association between adiponectin and the peripheral artery disease (pad) has not been well studied in hd patients without diabetic mellitus. materials and methods: the ankle-brachial index was measured in hd patients. adiponectin levels in 105 hd patie...