نتایج جستجو برای: adenoviruses human
تعداد نتایج: 1646338 فیلتر نتایج به سال:
Development of immunocompetent patient-like models that allow direct analysis of human adenovirus-based conditionally replicative adenoviruses (CRAds) would be beneficial for the advancement of these oncolytic agents. To this end, we explored the possibility of cross-species replication of human adenovirus type 5 (Ad5) in canine cells. With a panel of canine tumor cell lines of both epithelial ...
Using adenoviruses encoding reporter genes as retrograde tracers, we assessed the capacity of motoneurons to take up and retrogradely transport adenoviral particles injected into the muscles of transgenic mice expressing the G93A human superoxide dismutase mutation, a model of amyotrophic lateral sclerosis. Surprisingly, transgene expression in the motoneurons was significantly higher in sympto...
Cesium chloride-purified preparations of simian adenovirus 30 (SV30) were found to be oneogenic when inoculated into new born hamsters. Subcutaneous tumors developed in low incidence «2 %), and a histopathologic pattern similar to that induced by oneogenic human adenoviruses (25, 37, 51) was described. The neoplasm induced by SV30 and the biologic activity of the virus appear to have notable d...
BACKGROUND Oncolytic adenoviruses are an attractive strategy for treating cancers resistant to conventional treatments. However, their systemic utility could be limited as a result of the high prevalence of pre-existing immunity towards the vector. Furthermore, neutralizing antibodies (NAbs) may prevent successful intravenous readministration of the same agent. Previous preclinical reports indi...
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