Pattern recognition receptors (PRRs) are critical to the early detection and innate immune responses to pathogens. In particular, the toll-like receptor (TLR) system and its associated adaptor proteins have essential roles in early host responses to infection. Epidemic keratoconjunctivitis, caused by the human adenovirus, is a severe ocular surface infection associated with corneal inflammation...

A new class of virus-specific RNA molecules was found in cells transformed by group C human adenovirus types 2, 5, and 6. RNA isolated from virus-free rat embryo cells transformed by adenovirus 2, 5, and 6 hybridized with all group C adenovirus DNA's (adenovirus 1, 2, 5, and 6) equally well, but not appreciably with group A and B adenovirus DNA's. Most likely no viral genes common to group A, B...

Malmgren, Richard A. (National Cancer Institute; Bethesda, Md.), Alan S. Rabson, Paula G. Carney, and Frances J. Paul. Immunofluorescence of green monkey kidney cells infected with adenovirus 12 and with adenovirus 12 plus simian virus 40. J. Bacteriol. 91:262-265. 1966.-Immunofluorescence studies of the viral antigens and tumor (T) antigens of adenovirus 12 and simian virus 40 (SV40) in green ...

Vesicular stomatitis virus (VSV) leader RNA and a synthetic oligodeoxynucleotide of the same sequence were found to inhibit the replication of adenovirus DNA in vitro. In contrast, the small RNA transcribed by the VSV defective interfering particle DI-011 did not prevent adenovirus DNA replication. The inhibition produced by leader RNA was at the level of preterminal protein (pTP)-dCMP complex ...

Acute gastroenteritis (AGE) has a great impact on children less than five years of age, producing high levels of morbidity and mortality. Worldwide, AGE is mainly related to viruses, mainly rotavirus but human adenovirus (HAdV) in particular as an important etiologic agent. Among HAdV species F, genotypes 40 and 41 are responsible for a high number of diarrhea cases, mainly in children under 2 ...

The adenovirus DNA load ranged from 10(5) to 10(10) copy/mL and from 10(4) to 10(7) copy/mL in throat swabs and blood from patients with adenovirus-associated exudative tonsillitis, respectively. The copy number of adenovirus DNA in blood was positively correlated with the duration of the fever.

We describe 3 culture-proven cases of adenovirus serotype 14 infection in New Brunswick, Canada, during the summer of 2011. Strains isolated from severely ill patients were closely related to strains of a genomic variant, adenovirus 14p1, circulating in the United States and Ireland. Physicians in Canada should be aware of this emerging adenovirus.

Abstract Cutaneous lesions were observed in a wild population of freshwater turtles during routine disease surveillance at Alligator Creek, Townsville, Australia. Previous attempts to identify the causative agent these unsuccessful; however, existing evidence suggests viral etiology. To further investigate events, blood samples and lesion, oral cloacal swabs collected from 128 two locations (Al...

Adenovirus, es una enfermedad respiratoria aguda que afecta tanto al tracto respiratorio e intestinal. El objetivo fue brindar información actualizada sobre las características clínicas, sociodemográficas y factores de riesgo infecciones respiratorias agudas por Adenovirus. Se realizó investigación descriptiva, explicativa bibliográfica nos permitió recabar importante el tema propuesto. Pudimos...

Recombinant adenovirus vector systems have been used extensively in protein research and gene therapy. However, the construction and characterization of recombinant adenovirus is a tedious and time-consuming process. TIGIT is a recently discovered immunosuppressive molecule that plays an important role in maintaining immunological balance. The construction of recombinant adenovirus mediating TI...