In the search for new and effective prodrugs against the herpes simplex virus, a series of acyclovir analogues with a thiazole ring containing amino acids (glycine, alanine, valine, leucine) has been investigated. The chemical stability of some of the compounds containing different residues was studied at pH 1 and pH 7.4 at a temperature of 37°C. An HPLC method was developed for quantification ...

conclusions although melissa gel effectively reduced pain severity on the second and forth days, it was not effective to treat rhl. results there were no significant differences between the two groups considering the changes in the size of lesions, healing time and erythema around the lesion (except on the fourth day). pain severity alterations among the two groups showed significant difference...

OBJECTIVE To determine the cost of using systemic therapy to treat newly diagnosed cytomegalovirus (CMV) retinitis in persons with AIDS. DESIGN Incidence-based simulation model of CMV treatment from a government payer perspective. SETTING Swiss healthcare system. PATIENTS AND PARTICIPANTS Patients with AIDS and newly diagnosed CMV retinitis. INTERVENTIONS Patients were assigned to 1 of ...

A flow cytometric assay has been developed for the measurement of susceptibilities to ganciclovir of laboratory strains and clinical isolates of human cytomegalovirus (HCMV). The assay uses fluorochrome-labeled monoclonal antibodies to HCMV immediate-early and late antigens to identify HCMV-infected cells and flow cytometry to detect and quantitate the number of antigen-positive cells. By this ...

PURPOSE To evaluate the use of a flow-through diffusion cell system to assess the absorption and penetration characteristics of drug (acyclovir) products. METHODS In vitro studies were performed to assess the absorption/penetration of acyclovir using a flow-through diffusion cell system with human skin sections obtained from 19 healthy women following mammoplasty. The skin sections, 200-400 m...

BACKGROUND Epstein-Barr virus (EBV) is pathogenically linked to human immunodeficiency virus (HIV)-related primary central nervous system lymphoma (PCNSL) and is found in virtually all HIV-related PCNSL cases. The objective of this study was to assess the effect of ganciclovir on EBV DNA replication in patients with HIV-related PCNSL. PATIENTS AND METHODS EBV DNA was measured by real-time pol...

Acyclovir, a nucleoside analog, is thought to be specific for the human herpesviruses because it requires a virally encoded enzyme to phosphorylate it to acyclovir monophosphate. Recently, acyclovir triphosphate was shown to be a direct inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Here, we showed that acyclovir is an inhibitor of HIV-1 replication in CD4(+) T ...

Abstract: Background: Acyclovir is a potent antiviral agent primarily used to treat viral infection in the eye, signified as Herpes Simplex Keratitis caused by Virus-1. But its applications are limited because of poor oral bioavailability and permeability significant first-pass metabolism. Objectives: The study design formulation, optimization, in-vitro, ex-vivo in-vivo characterization solid l...