BACKGROUND Inflammation has a pathogenetic role in acute myocardial infarction (MI). Pentraxin-3 (PTX3), a long pentraxin produced in response to inflammatory stimuli and highly expressed in the heart, was shown to peak in plasma approximately 7 hours after MI. The aim of this study was to assess the prognostic value of PTX3 in MI compared with the best-known and clinically relevant biological ...

BACKGROUND The Acute Cardiovascular Care Association defined quality indicators (QIs) for the management of acute myocardial infarction. The application of these QIs to existing databases is appealing. It remains to be determined what the rates of implementation are, how the QIs are related to long-term survival, and whether quality categorization is possible. METHODS AND RESULTS The QIs were...

Chronic heart failure after ST-segment–elevation myocardial infarction (MI) remains a public health burden despite current percutaneous interventional and pharmacological treatment. Strategies to reduce infarct size are needed but remain a therapeutic challenge. Insulin-like growth factor-1 (IGF-1) is a known central regulator of cardiac function with prosurvival, proliferative, and differentia...

Chronic heart failure after ST-segment–elevation myocardial infarction (MI) remains a public health burden despite current percutaneous interventional and pharmacological treatment. Strategies to reduce infarct size are needed but remain a therapeutic challenge. Insulin-like growth factor-1 (IGF-1) is a known central regulator of cardiac function with prosurvival, proliferative, and differentia...

Abstract Purpose of Review In acute ST-segment elevation myocardial infarction (STEMI), successful restoration blood flow in the infarct-related coronary artery may not secure effective reperfusion. The mortality and morbidity associated with MI remain significant. Microvascular obstruction (MVO) represents failed microvascular MVO is under-recognized, independently adverse cardiac prognosis an...

Chronic heart failure after ST-segment–elevation myocardial infarction (MI) remains a public health burden despite current percutaneous interventional and pharmacological treatment. Strategies to reduce infarct size are needed but remain a therapeutic challenge. Insulin-like growth factor-1 (IGF-1) is a known central regulator of cardiac function with prosurvival, proliferative, and differentia...

Chronic heart failure after ST-segment–elevation myocardial infarction (MI) remains a public health burden despite current percutaneous interventional and pharmacological treatment. Strategies to reduce infarct size are needed but remain a therapeutic challenge. Insulin-like growth factor-1 (IGF-1) is a known central regulator of cardiac function with prosurvival, proliferative, and differentia...

Chronic heart failure after ST-segment–elevation myocardial infarction (MI) remains a public health burden despite current percutaneous interventional and pharmacological treatment. Strategies to reduce infarct size are needed but remain a therapeutic challenge. Insulin-like growth factor-1 (IGF-1) is a known central regulator of cardiac function with prosurvival, proliferative, and differentia...

Objectives: This study aimed to investigate the efficacy of calcitriol on Ischemia-reperfusion Injury (IRI) and inflammatory biomarkers in patients with non-ST-segment elevation acute coronary syndromes (NSTEACS) undergoing elective Percutaneous Coronary Intervention (PCI). Methods: A total of 72 patients with NSTEACS were randomly divided into two groups: (1) the calcitriol-treated grou...

Abstract Background Stress has been recognized as a cardiovascular risk factor that aside from triggering acute coronary syndromes (acute stress), could also directly and indirectly mediate the pathophysiology of artery disease (chronic stress). So far, there have no quantitative indices available to study this relationship. Purpose We prospectively investigated stress levels for days prior epi...