This study was conducted to investigate the etiology, the clinical characteristics and prognosis of acute necrotizing encephalopathy (ANE) in Korean children. Six children (1 yr to 7 yr) patients with ANE were enrolled. They were diagnosed by clinical and radiological characteristics and their clinical data were retrospectively analyzed. In a search of clinically plausible causes, brain MRI in ...

Background: Opioid sensitivity is well known to vary widely among individual subject in levels of μ-opioid receptor (MOP) expression, responses to pain and analgesic effect of morphine. Many studies have reported that the single nucleotide polymorphism (SNP), A118G, of the μ-opioid receptor gene (OPRM1) has been shown to be associated with MOP expression levels, as well as pain thresholds, anal...

Introduction: Necrotizing fasciitis is a life-threatening soft-tissue infection characterized by a fulminant course and high mortality. Diagnosis of necrotizing fasciitis is often difficult, because nascent NF often appears deceptively benign and lack specific diagnostic clues. In addition, the manifestations of NF are similar to those of acute limb ischemia. Here, we introduce the case of necr...

After infection with the neurotropic CAM/RBH measles virus (MV) strain, newborn Lewis rats succumb to an acute necrotizing encephalopathy. Passive transfer of neutralizing monoclonal antibodies directed against MV hemagglutinin prevented this disease process. Instead, either an antibody-induced acute or subacute measles encephalitis developed after a prolonged incubation period with a restricte...

BACKGROUND AND PURPOSE The clinical outcome of acute necrotizing encephalopathy of childhood (ANEC), an encephalopathy characterized by symmetrical involvement of the thalami, has historically been poor, but recent studies have reported better outcomes. By devising a MR imaging scoring system, we determined the relationship between characteristic MR findings and clinical outcome of patients wit...

Background Acute hemorrhagic encephalomyelitis (AHEM) is considered as a rare form of acute disseminated encephalomyelitis characterized by fulminant encephalopathy with hemorrhagic necrosis and most often fatal outcome. Objective To report the association with Ran Binding Protein (RANBP2) gene variant and the response to decompressive craniectomy and high-dose intravenous methylprednisolone ...

INTRODUCTION Posterior reversible encephalopathy syndrome is an extremely rare radiological diagnosis that has not been reported previously in association with acute liver failure. CASE PRESENTATION A 6-year-old Sri Lankan girl developed acute liver failure with severe hepatic encephalopathy due to sodium valproate. She was successfully treated medically with N-acetylcysteine and L-carnitine....