Multiparametric flow cytometry is an alternative approach to the polymerase chain reaction method for evaluating minimal residual disease in treatment protocols for primary acute lymphoblastic leukemia. Given considerable differences between primary and relapsed acute lymphoblastic leukemia treatment regimens, flow cytometric assessment of minimal residual disease in relapsed leukemia requires ...

Abstract Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Ig?), signaling component preB cell receptor (preBCR), to be associated with CNS-infiltration –relapse B-cell precursor (BCP)-ALL patients. Furthermore, show that downregulation hampers engraftment cells diffe...

Although childhood acute lymphoblastic leukemia is the most common pediatric cancer, its etiology remains poorly understood. In an attempt to replicate the findings of 2 recent genome-wide association studies in a French-Canadian cohort, we confirmed the association of 5 SNPs [rs7073837 (P=4.2 x 10(-4)), rs10994982 (P=3.8 x 10(-4)), rs10740055 (P=1.6 x 10(-5)), rs10821936 (P=1.7 x 10(-7)) and r...

In contrast to acute lymphoblastic leukemia in children, adult cases of this disease are associated with a very poor prognosis. In order to ascertain whether the frequencies and patterns of submicroscopic changes, identifiable with single nucleotide polymorphism array analysis, differ between childhood and adult acute lymphoblastic leukemia, we performed single nucleotide polymorphism array ana...

We will be describing our experience with five patients diagnosed acute lymphoblastic leukemia (ALL), who developed L-Asparaginase (L-Asp)-induced pancreatitis during their remission induction stage. The were treated, at the State Cancer Center of Durango, Mexico (CECAN-Durango) since December 2021, along a group 30 pediatric (in phase treatment) did not develop pancreatitis.

Background The most common malignancy of children is Leukemia, accounting approximately one third of cancer diagnosis. Available data demonstrate improvement in survival of pediatric leukemia, so evaluation of side effects of treatment is very important. This study investigates hyperglycemia and diabetes mellitus prevalence in pediatric patients with acute leukemia. Materials and Methods T...

Objective: To describe certain characteristics of acute leukemia regarding age, gender, cytomorphology and immunophenotype at King Hussein Medical Center. Methods: A retrospective review of bone marrow aspirate and/or biopsy reports was conducted at Princess Iman Research and Laboratory Sciences Center at King Hussein Medical Center during the period between Jan 2004 and Dec 2008. A total of 22...

BACKGROUND Treatment response has become one of the most important prognostic factors in childhood acute lymphoblastic leukemia. We evaluated the significance of the complete clearance of peripheral leukemic blasts on survival in children with acute lymphoblastic leukemia. DESIGN AND METHODS Seven hundred and fifty-four children diagnosed with acute lymphoblastic leukemia, consecutively enrol...

Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T-cell acute lymphoblastic leukemias, supporting a role as an essential driver for this gene in T-...

ALL: acute lymphoblastic leukemia INTRODUCTION Blinatumomab is the first-in-class bispecific T-cell engager antibody approved for the treatment of refractory acute lymphoblastic leukemia (ALL). It simultaneously binds endogenous CD3 cytotoxic T cells and CD19 B cells, resulting in T-celle mediated serial lysis of normal and malignant B cells. Although studies have been conducted into the incide...