1228 The measurement of cardiac troponins (cTn) is widely used to diagnose myocardial injury or necrosis, and has become an important tool for the risk stratification and clinical management of patients with acute coronary syndrome (ACS). However, elevated cTn levels are also found in nonACS patients. For example, in a recent study of patients with chronic stable coronary artery disease, higher...

BACKGROUND AND PURPOSE Despite availability of an approved drug to treat acute cerebral ischemia, most patients with stroke do not realize a good outcome. A method that would rapidly increase or restore cerebral perfusion before irreversible cell death should improve patient outcomes. MATERIALS AND METHODS We recently had the opportunity to treat 6 middle-aged-to-elderly patients who presente...

objectives: curcumin has anti-inflammatory and antioxidative properties. the objective of this study was to investigate the therapeutic effects of curcumin on functional disturbances, oxidative stress, and leukocyte infiltration induced by renal ischemia/reperfusion (i/r). materials and methods: animals were randomly divided into 9 groups. the groups with 24-h reperfusion consisted of sham-24h,...

Cerebral ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demands. This leads to poor oxygen supply or cerebral hypoxia and thus leading to the death of brain tissues or cerebral infraction/ischemia stroke. It has been third most common cause of death in developed countries, Stroke can affect walking, talking, speech, vision, spatial awareness, sw...

Abstract Background The recent advances in magnetic resonance imaging techniques have improved the assessment of acute stroke. Susceptibility weighted (SWI) has a crucial role management plan cerebral ischemia. This study was aimed to assess susceptibility-weighted area at risk (pneumbra) compared CT perfusion patients with ischemic infraction. Results We found mean aspect score for SWI 4 ± 1.4...

 Background: The role of uric acid as a risk factor for vascular disease and acute stroke is controversial and there is little information about it. In this study, we determined serum uric acid levels in patients with acute stroke and assessed its relationship with cerebrovascular risk factors. Methods: In this cross sectional study, we assessed patients with acute stroke who were admitted in F...

BACKGROUND The use and benefits of normobaric oxygen (NBO) in patients suffering acute ischemic stroke is still controversial. RESULTS Here we show for the first time to the best of our knowledge that NBO reduces both NMDA-induced calcium influxes in vitro and NMDA-induced neuronal degeneration in vivo, but increases oxygen and glucose deprivation-induced cell injury in vitro and ischemia-ind...

A healthy 27-year-old female presented to the hospital after she collapsed an hour into her first marathon run on a hot humid day. On presentation, she was hyperthermic, encephalopathic, tachycardic, and hypotensive. On admission, she was found to have lactic acidosis, rhabdomyolysis, and acute kidney injury and was treated with cold normal saline and cooling blankets. She subsequently started ...

Acute brain ischemia modifies synaptic plasticity by inducing ischemic long-term potentiation (iLTP) of synaptic transmission through the activation of N-Methyl-D-aspartate receptors (NMDAR). Thrombin, a blood coagulation factor, affects synaptic plasticity in an NMDAR dependent manner. Since its activity and concentration is increased in brain tissue upon acute stroke, we sought to clarify whe...

BACKGROUND AND PURPOSE Ethanol consumption is inversely associated with the risk of ischemic stroke, suggesting a neuroprotective effect. In a rat model of transient cerebral ischemia, we identified ethanol as a possible treatment for acute ischemic stroke. METHODS Sprague-Dawley rats were subjected to middle cerebral artery occlusion for 2 hours. Five sets of experiments were conducted: to d...