نتایج جستجو برای: activin a

تعداد نتایج: 13432651  

2017
Maria Antsiferova Aleksandra Piwko-Czuchra Michael Cangkrama Mateusz Wietecha Dilara Sahin Katharina Birkner Valerie C Amann Mitchell Levesque Daniel Hohl Reinhard Dummer Sabine Werner

Activin has emerged as an important player in different types of cancer, but the underlying mechanisms are largely unknown. We show here that activin overexpression is an early event in murine and human skin tumorigenesis. This is functionally important, since activin promoted skin tumorigenesis in mice induced by the human papillomavirus 8 oncogenes. This was accompanied by depletion of epider...

Journal: :Developmental biology 2008
Shiona M Coutts Andrew J Childs Norma Fulton Craig Collins Rosemary A L Bayne Alan S McNeilly Richard A Anderson

Ovarian germ cell survival is dependent upon the formation of primordial follicles, which occurs during fetal life in the human. Activin contributes to germ cell proliferation and survival at this time. SMADs2 and 3 are central elements in the activin signalling pathway and thus indicate sites of activin action. We have investigated the expression and localisation of SMADs2 and 3 in the fetal o...

Journal: :Endocrinology 1997
I Caniggia S J Lye J C Cross

Cytotrophoblast cells of the first trimester placenta are highly invasive when removed from villi and cultured in vitro. In vivo, however, only selected cytotrophoblast cells break through the overlying syncytiotrophoblast to form cytotrophoblast columns and ultimately invade the endometrium. To explore the role of paracrine growth factors in regulating cytotrophoblast development, we cultured ...

Journal: :PLoS ONE 2008
Hiroshi Ageta Akiko Murayama Rika Migishima Satoshi Kida Kunihiro Tsuchida Minesuke Yokoyama Kaoru Inokuchi

Activin, a member of the transforming growth factor-beta superfamily, is an endocrine hormone that regulates differentiation and proliferation of a wide variety of cells. In the brain, activin protects neurons from ischemic damage. In this study, we demonstrate that activin modulates anxiety-related behavior by analyzing ACM4 and FSM transgenic mice in which activin and follistatin (which antag...

Journal: :Molecular human reproduction 2008
M C Ferreira C A Witz L S Hammes N Kirma F Petraglia R S Schenken F M Reis

The aim of this study was to investigate whether activin A has an effect on the attachment and/or invasion of endometrial cells in a modeled peritoneum in vitro. Cultured endometrial stromal cells (ESCs) and endometrial epithelial cells (EECs) were treated with activin A (6.25-50 ng/ml) and with activin A (25 ng/ml) with and without inhibin A or follistatin. Fluorescent labeled cells were added...

Journal: :Circulation 2004
Arne Yndestad Thor Ueland Erik Øie Geir Florholmen Bente Halvorsen Håvard Attramadal Svein Simonsen Stig S Frøland Lars Gullestad Geir Christensen Jan Kristian Damås Pål Aukrust

BACKGROUND Although modulation of inflammatory processes has been suggested as a new treatment modality in heart failure (HF), our knowledge about abnormalities in the cytokine network during HF is still limited. On the basis of a previous cDNA array study examining peripheral blood mononuclear cells from HF patients, we hypothesized a role for activin A, a member of the transforming growth fac...

Journal: :Genetics and molecular research : GMR 2015
L L Zhang C T Liu

There are limited data regarding the effects of activin A on underweight, normal weight, and overweight patients with asthma. We determined serum levels of activin A in asthmatic patients in relation to body mass index. The study protocol included questionnaires, measurement of exhaled nitric oxide, blood sampling for inflammatory biomarkers, and high-resolution computed tomography of the lungs...

Journal: :The Journal of clinical endocrinology and metabolism 1998
F Petraglia P Florio S Luisi R Gallo A Gadducci P Viganò A M Di Blasio A R Genazzani W Vale

Inhibins and activins are growth factors belonging to the transforming growth factor-beta) family and are known to influence cell proliferation and differentiation. Because transforming growth factor-beta is involved in physiological and tumoral changes of uterine tissues, the present study aimed to evaluate whether human normal and neoplastic endometrial and cervical epithelial cells express a...

2016
Siyuan Xiong Christian Klausen Jung-Chien Cheng Peter C.K. Leung

High-risk type II endometrial cancers account for ~30% of cases but ~75% of deaths due, in part, to their tendency to metastasize. Histopathological studies of type II endometrial cancers (non-endometrioid, mostly serous) suggest overproduction of activin B and down-regulation of E-cadherin, both of which are associated with reduced survival. Our previous studies have shown that activin B incre...

2014
Ingrid Wacker Jürgen Behrens

Activin B belongs to the TGFβ family of growth factors and is upregulated in clear cell renal cell carcinoma cells by hypoxia inducible factors. Expression of Activin B is required for tumor growth in vivo and tumor cell invasion in vitro. Here we show that activation of RhoA signaling counteracts Activin B mediated disassembly of actin stress fibers, mesenchymal cell morphology and invasivenes...

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