Carbon ion radiotherapy at HIMAC started in 1994 using two horizontal and two vertical beam ports with broad beam method. The maximum beam energy extracted from accelerators was 400 MeV/n for the horizontal beam port, and 350 MeV/n for the vertical one. In recent years, the scope of diseases that can be treated by the carbon ion radiotherapy has widened and their tumor targets have varied in di...

The design and performance of a beam profile monitor which presents no material to the beam is described. The detector, which has a 75 mm active width, operates from residual gas in the beam vacuum system . It provides 1 mm rms spatial resolution and 1 ms time resolution in a 1 ALA beam at 10-7 Torr . Using a microprocessor based scanning ADC, a sequence of ten profiles can be acquired in as li...

(Dated: June 3, 2001) At several locations of the beam delivery system (BDS) of a future linear collider (FLC), beam spot sizes ranging from several hundreds to a few micrometers have to be measured. The large demagnification of the beam in the BDS and the high beam power puts extreme conditions on any measuring device. With conventional techniques at their operational limit in FLC scenarios, n...

nanoparticles have been at the center of research focus as a new promising material for the treatment of cancer in recent years. although many chemotherapy drugs for cancer treatment are available, their potential toxicity is the main point of concern. on the other hand, the conventional chemotherapeutic approach has not been found to be very efficient in colorectal cancer (crc) as the drug mol...

since its original conception in 1959, by nobel physicist richard p feynman, the notion of nanotechnology and its potential ramifications have not only created fascination,but also intense scientific efforts and scrutiny. one of the most promising applications of nanotechnology is in the context of medicine. due to their unique size-dependent properties nanomaterials such as nanoparticles offer...

background: several multiphase flow analyses have been developed to predict the fate of particles used in inhalation drug delivery; however, the collapse of droplets during their passage through respiratory tract has not been investigated. objective: to assess the probability of droplet collapse in the upper respiratory tract. methods: a 3d model of mouth-to-second generation airway after the t...

conclusions it was shown that combination of pectin and eudragits can relatively control drug release in the upper gi. on the other hand, pectin degraded in the presence of pectinase and formulations were susceptible to the colonic media. results it was shown that in the presence of pectin, formulations without erl had a relative resistance to drug release in sgf. pellets containing pectin and ...

PURPOSE We report on an integrated system for real-time adaptive radiation delivery to moving tumors. The system combines two promising technologies-three-dimensional internal position monitoring using implanted electromagnetically excitable transponders and corresponding real-time beam adaptation using a dynamic multileaf collimator (DMLC). METHODS AND MATERIALS In a multi-institutional acad...

The aim of this work was to track and verify the delivery of respiratory-gated irradiations, performed with three versions of TrueBeam linac, using a novel phantom arrangement that combined the OCTAVIUS(®) SRS 1000 array with a moving platform. The platform was programmed to generate sinusoidal motion of the array. This motion was tracked using the real-time position management (RPM) system and...

In pharmaceutical industry, various controlled released dosage forms like solid formulation, semi solid formulation and topical preparation have more importance due to efficacy and patient compliance. Topical preparations have some disadvantages like unpleasant odour, greasiness and skin irritation and fail to reach the systemic circulation in sufficient amounts in few cases. This problem is ov...