background and objectives: presence of steroid hormone receptors (estrogen and progesterone) in the tumor tissues of various organs correlates with response to therapy and prognosis. since their role in ovarian cancer is still controversial, in this study we investigated the expression and prognostic value of the estrogen receptor (er) and progesterone receptors (pr) in ovarian papillary serous...

Abstract Th17-cells play a key role in the pathogenesis of autoimmune hepatitis (AIH), severe hepatopathy characterized by hypergammaglobulinemia, seropositivity for autoantibodies and interface on histology. Aberrant Th17-cell response AIH is linked to alterations aryl-hydrocarbon-receptor (AHR) signaling. These result inability respond AHR activation. Since can be regulated upon binding aryl-...

some lesions in the oral cavity and mostly on gingiva have predominant predilection towards females, and mostly occur in the first four decades of life when changes in sex hormone levels in blood are obvious. the present study aimed to investigate the presence and distribution of estrogen and progesterone receptors in peripheral giant cell granuloma (pgcg), pyogenic granuloma (pg) and periphera...

Abstract The leptin-melanocortin pathway is playing a pivotal role for central body weight regulation. melanocortin 4 receptor (MC4R) essential to induce satiety after activation by the endogenous ligands α-/β-melanocyte-stimulating hormone. relevance of biased signaling exemplified an MC4R agonist, which has been approved treatment rare forms monogenic obesity. Here discussed as new option dev...

Although V 1B R mRNA has been detected in the kidney, precise renal localization as well pharmacological and physiological properties of this receptor remain unknown. Using original pharmaceutical tools, study brings new data on signaling pathways R, highlights a cross talk between 2 (V R) inner medullary collecting duct, suggests that may counterbalance some pathophysiological conditions antid...