Sulfur mustard (SM), a chemical warfare agent, is strong alkylating compound that readily reacts with numerous biomolecules. The goal of the present work was to define and validate new biomarkers exposure SM could be easily accessible in urine or plasma. Because investigations using are prohibited by Organization for Prohibition Chemical Weapons, we worked 2-chloroethyl ethyl sulfide (CEES), mo...

background: acrylamide (c3h5no) is a vinyl monomer. this water-soluble crystalline solid is a colorless, odorless agent which is used in scientific laboratories and some industries. acrylamide has cellular oxidative effects. acute or chronic poisoning with this agent happens as a result of skin, respiratory, or oral contacts. clinical manifestations depend on the dose, duration, and frequency o...

We previously reported that disruption of the yjbI gene reduced virulence Staphylococcus aureus. In this study, we found in both silkworms and mice was restored by introducing yjbH but not to genes-disrupted mutants, suggesting yjbH, downstream a two-gene operon-yjbIH, is responsible for phenomenon. further observed decrease various surface-associated proteins changes cell envelope glycostructu...

N-acetyl-L-cysteine (NAC) and cysteine have been implicated in a number of human neutrophils' functional responses. However, though Ca(2+) signaling is one of the key signalings contributing to the functional responses of human neutrophils, effects of NAC and cysteine on intracellular calcium concentration ([Ca(2+)]i) in human neutrophils have not been investigated yet. Thus, this study was car...

In this study, using two different injury models in two different species, we found that early post-injury treatment with N-Acetyl Cysteine (NAC) reversed the behavioral deficits associated with the TBI. These data suggest generalization of a protocol similar to our recent clinical trial with NAC in blast-induced mTBI in a battlefield setting, to mild concussion from blunt trauma. This study us...

A cell extract of an extremely thermophilic bacterium, Thermus thermophilus HB8, cultured in a synthetic medium catalyzed cystathionine gamma-synthesis with O-acetyl-L-homoserine and L-cysteine as substrates but not beta-synthesis with DL-homocysteine and L-serine (or O-acetyl-L-serine). The amounts of synthesized enzymes metabolizing sulfur-containing amino acids were estimated by determining ...

Background: Fatalities from acetaminophen poisoning are common, but they are preventable by timely treatment with N-acetyl cysteine (NAC). In many medical centers, NAC is prescribed in keeping with the ingested dose of the drug as revealed through medical history. It seems to significantly differ from the real indications of NAC administration based on plasma level of acetaminophen. Overtreat...

Introduction: The model for screening antidepressant-like activity in pre-clinical drug studies include, rat forced swimming test (FST). The reports on N-acetylcysteine (NAC) as an antioxidant supplement in stress related disorder is well documented. This study was aimed at potential antidepressant mechanism of N- Acetyl Cysteine (NAC), a glutamate precursor on FST animal model for screening an...

Introduction: Several studies in the literature have evaluated role of oxidative stress and adjuvant therapies for X-linked adrenoleukodystrophy (X-ALD). Here, we investigated whether n-acetyl-L-cysteine (NAC) rosuvastatin (RSV) could influence generation reactive species, redox status nitrative fibroblasts from asymptomatic patients with X-ALD. Methods: Skin biopsy samples were cultured treate...