The activity and properties of cholinesterase of the motor end plate in human intercostal muscle were studied in the isolated muscle membrane. This preparation was used because cholinesterase activity of the membrane preparation was localized in the motor end plate without contamination of cholinesterase of other muscle components. Under the experimental conditions, cholinesterase in a human en...

We investigated the role of the septo-hippocampal cholinergic projection in anxiety, spatial novelty preference, and differential reward for low rates of responding (DRL) performance. Cholinergic neurons of the rat medial septum (MS) and the vertical limb of the diagonal band of Broca (VDB) were lesioned using the selective immunotoxin, 192 IgG-saporin. Rats were then tested on several behavior...

Bioassay guided fractionation of an ethanol extract of leaves of Canarium patentinervium Miq. (Burseraceae Kunth.) led to the isolation of scopoletin. The structure of this coumarin was elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D) and mass spectrometry. Scopoletin inhibited the enzymatic activity of 5-lipoxygenase and acetyl cholinesterase with ...

The morphological and histochemical changes in muscle biopsies from 6 cases with myasthenia gravis (MG) were studied, The patients were misdiagnosed at the initial presentation, however they were all proved later by either histochmical and serological tests or improvement on mestinone therapy to have MG. Here, the histomorphological and histochemical changes that were seen in muscle biopsies of...

The distribution of cholinesterase (Ch-esterase) in isolated myelinated fibers of the frog has been investigated. Quantitative microgasometric measurements have confirmed the previous histochemical observations. Both approaches indicate that in frog nerve fibers acetylcholinesterase (ACh-esterase) is the only or the predominant enzyme when selective inhibitors and different substrates are used:...

Hypertension, also known as high or raised blood pressure, is a multifactorial disease with multiple causes and treatments. The prevalence of hypertension in the urban Indian population was estimated to be 40.8% rural 17.9%. Though there are treatment still it challenge manage this effectively lower side effects all available treatments full toxic effects. NIA/DG/2020/01 new anti-hypertensive A...

Substance concentrations of plasma cholinesterase (EC 3.1.1.8) were measured in 94 healthy individuals without occupational exposure to known inhibitors (six samples from each individual). Immunoreactive cholinesterase substance concentrations showed an inter-individual variation corresponding to CVtotal = 22% (mean: 5.01 mg/l, SD: 1.11 mg/l). Intra-individual variations of immunoreactive choli...

Increase in blood glucose levels can be caused by the long-term use of pesticides farmers. This study aims to determine whether there is a correlation between activity cholinesterase as an indicator exposure and farmers Mlokorejo Village, Jember Regency. The research method observational-analytic with cross-sectional design. Data form general characteristics sample were obtained through intervi...

Cholinesterase activity in blood of laboratory rats was monitored. Rats were intoxicated with paraoxon at dosis of 0 - 65 - 125 - 170 - 250 - 500 nmol. The 250 nmol dose was found to be the LD(50). An electrochemical sensor was found useful to provide information about cholinesterase activity. The decrease of cholinesterase activity was correlated to intoxication symptoms and mortality level. I...