BACKGROUND Cutaneous leishmaniasis (CL) is a neglected infectious disease and a major health problem in several developing countries. Despite some reasonable explanation for their potential benefits, there is only trace evidence regarding the role of dressings in the treatment of CL. METHODS This randomized, assessor-blind, controlled, clinical trial was conducted in an endemic area for CL ca...

Question: Does group exercise prevent lumbopelvic pain during and after pregnancy? Design: Randomised controlled trial. Setting: A University hospital clinic and three outpatient physiotherapy clinics in Norway. Participants: Three hundred and one healthy, nulliparous women at 20 weeks of pregnancy. Pregnancy complications and high risk for preterm labour were exclusion criteria. Interventions:...

OBJECTIVE The study sought to examine the total weight of evidence regarding the use of drug eluting (DES) and bare metal stents (BMS) in patients with end stage renal disease (ESRD). BACKGROUND The potential superiority of DES over BMS in reducing target lesion or vessel revascularization (TLR or TVR) in patients with ESRD on dialysis has not been established. Small studies comparing DES to ...

Purpose: In REDUCE, dutasteride was associated with a ~5% absolute reduction in the risk of biopsydetected prostate cancer (PCa). Material and methods: We tested the influence of family history on the association between dutasteride and PCa diagnosis and calculated the number needed to treat (NNT) with dutasteride to avoid one PCa diagnosis. The REDUCE trial tested dutasteride 0.5mg/day for PCa...

OBJECTIVE To determine whether there is an association between being smacked by your main caregiver in the first two years and emotional and behavioural problems at age four. METHODS DESIGN Secondary analysis of data from the Growing Up in Scotland Prospective Study (GUS). SETTING Scotland, UK. PARTICIPANTS GUS birth cohort children, whose main caregiver had no concerns about their beh...

BACKGROUND Healthy People 2020 aim to reduce fatal atherosclerotic cardiovascular disease (ASCVD) by 20%, which translates into 310 000 fewer events annually assuming proportional reduction in fatal and nonfatal ASCVD. We estimated preventable ASCVD events by implementing the American College of Cardiology/American Heart Association (ACC/AHA) 2013 Cholesterol Guideline in all statin-eligible ad...

BACKGROUND For physicians dealing with patients with a limited life expectancy, knowing the time to benefit (TTB) of preventive medication is essential to support treatment decisions. OBJECTIVE The aim of this study was to investigate the usefulness of statistical process control (SPC) for determining the TTB in relation to fracture risk with alendronate versus placebo in postmenopausal women...

BACKGROUND Routine general practice data collection can help identify patients at risk of cardiovascular disease. AIM To determine whether a training programme for primary care professionals improves the recording of cardiovascular disease risk factors in electronic health records. DESIGN AND SETTING A quasi-experimental study without random assignment of professionals. This was an educatio...

The Far InfraRed Absolute Spectrophotometer (FIRAS) was built to measure the spectrum of diiuse emission from 1 to 100 cm ?1 , with particular attention to possible diierences between the spectrum of the cosmic microwave background radiation (CMBR) and a blackbody spectrum as small as 0.1% of the peak of the CMBR spectrum. The FIRAS has diierential inputs and outputs, a full beam external calib...