Earth’s atmospheric turbulence induces aberrations in the wavefront of the optical signal from a distant spacecraft. These aberrations cause diffusion and spreading of the signal energy in the receiver’s focal plane, potentially resulting in an increase in bit-error rate (BER) by several orders of magnitude when significant background radiation is present, such as during daytime operation. The ...

Two general types of clonal chromosome abnormality are observed in de novo acute myeloid leukemia (AML): the unbalanced aberrations with visible gain or loss of chromosome material and the balanced aberrations without such visible gain or loss. AML can be induced by therapy with cytostatic drugs and radiation. The alkylating agents reacting directly with DNA induce AML which often presents as m...

BACKGROUND The aggressive biology of cancers arising in adolescent and young adult (AYA; ages 15-39 years) patients is thought to contribute to poor survival outcomes. METHODS We used clinical next-generation sequencing (NGS) results to examine the molecular alterations and diverse biology of cancer in AYA patients referred to the Phase 1 program at UT MD Anderson Cancer Center. RESULTS Amo...

The imaging performance of an optical microscope can be degraded by sample-induced aberrations. A general strategy to undo the effect of these aberrations is to apply wavefront correction with a deformable mirror (DM). In most cases the DM is placed conjugate to the microscope pupil, called pupil adaptive optics (AO). When the aberrations are spatially variant an alternative configuration invol...

An optical analysis is developed to separate forward light scatter of the human eye from the conventional wavefront aberrations in a double pass optical system. To quantify the separate contributions made by these micro- and macro-aberrations, respectively, to the spot image blur in the Shark-Hartmann aberrometer, we develop a metric called radial variance for spot blur. We prove an additivity ...

Further development of the objective version of the Howland and Howland [(1976) Science, 193, 580-582; (1977) Journal of the Optical Society of America, 67, 1508-1518] aberroscope technique for measuring ocular aberrations is described. Compensation for refractive corrections and calibration is discussed. The technique was used to investigate the effect of accommodation upon the monochromatic a...

In optical imaging systems, the wavelength-dependency of the refraction indices of lenses causes chromatic aberrations: electromagnetic radiation from an object point is dispersed in a rainbow-like manner on the sensor. These aberrations were so far only measured and modeled for up to three, often relatively wideband wavelength bands like R, G and B. Moreover, no relation between the aberration...

Two general types of clonal chromosome abnormality are observed in de novo acute myeloid leukemia (AML): the unbalanced aberrations with visible gain or loss of chromosome material and the balanced aberrations without such visible gain or loss. AML can be induced by therapy with cytostatic drugs and radiation. The alkylating agents reacting directly with DNA induce AML which often presents as m...

The importance of chromosomal aberrations as a proximate cause of bone marrow toxicity is discussed. Since chemicals that can cause nondisjunction are rare, numerical aberrations (aneuploidy, polyploidy) are not ordinarily important. Many structural aberrations, however, can lead directly to cell death and so are proximate causes of toxicity when they occur. The micronucleus test which utilizes...

purpose: to evaluate the correlation between refractive, corneal and lenticular astigmatism and higher order aberrations (hoa) in refractive surgery candidates methods: this cross-sectional descriptive-analytical study consisted of 400 eyes (200 patients) who were referred between 2011 to 2013 to farabi eye hospital for refractive surgery. refraction, topography and aberrometry were performed t...