An immunopeptide bearing a3 allotypic determinant(s) was isolated from the y chain of an a3 homozygous rabbit (G222-2) immunized with type III pneumococcal vaccine. Immunological properties of peptides were studied using a radioimmunoassay that involved inhibition by these peptides of a reaction between ““I-labeled anti-a3 antibody and Sepharose-bound a3 immunoglobulin G (IgG). The y chain was ...

The cross-coupling reaction between phenylboronic acid and various types of aryl halides (Suzuki reaction) was carried out using a catalytic amount of a new palladium catalyst (1-benzyl-3-(1-benzyl-1-methylpyrrolidin-1-ium-2-yl) pyridin-1-ium palladium chloride [DBNT][PdCl4]) in poly (ethylene glycol) (PEG-200) in the presence of KOH as the base. This new catalyst was synthesized and...

Little is known about the repertoire of MAGE-A3 CD4(+) T-cell epitopes recognized in vivo by neoplastic patients and how antigen processing influences epitope formation. Here, we first show that MAGE-A3-specific CD4(+) T cells are present in the blood of advanced melanoma patients. MAGE-A3(111-125), MAGE-A3(191-205), and MAGE-A3(281-300) were recognized by 7, 6, and 5 of the 11 patients tested,...

Done all A–1 Determine, with proof, the number of ordered triples (A1, A2, A3) of sets which have the property that (i) A1 ∪A2 ∪A3 = {1, 2, 3, 4, 5, 6, 7, 8, 9, 10}, and (ii) A1 ∩A2 ∩A3 = ∅. Express your answer in the form 2357, where a, b, c, d are nonnegative integers. Solution: For each integer i from 1 to 10 you must put i in one of 6 sets: A1 ∩ A2 ∩ A3 or A1 ∩ A2 ∩ A3 or A1 ∩ A2 ∩ A3 or A1...

In this paper we show that del Pezzo surfaces of degree 1 with Du Val singular points of type A4, A4 + A4, A4 + A3, A4 + 2A1, A4 + A1, A3 + 4A1, A3 + 3A1, 2A3 + 2A1, A3 + 2A1, A3 + A1, 2A3, A3, admit a Kähler-Einstein metric. Moreover we are going to compute global log canonical thresholds of del Pezzo surfaces of degree 1 with Du Val singularities, and of del Pezzo surfaces of Picard group Z w...

Urea has a critical role in urinary concentration. Mice lacking the inner medullary collecting duct (IMCD) urea transporter A1 (UT-A1) and urea transporter A3 (UT-A3) have very low levels of urea permeability and are unable to concentrate urine. To investigate the role of UT-A1 in the concentration of urine, we transgenically expressed UT-A1 in knockout mice lacking UT-A1 and UT-A3 using a cons...

The Eschenmoser coupling is a useful carbon-carbon bond forming reaction which has been used in various different synthesis strategies. The reaction proceeds smoothly if S-alkylated ternary thioamides or thiolactames are used. In the case of S-alkylated secondary thioamides or thiolactames, the Eschenmoser coupling needs prolonged reaction times and elevated temperatures to deliver valuable yie...

We newly developed lithium methyltriolborate as an air-stable white solid that is convenient to handle. The good performance of this triolborate for metal-catalyzed bond-forming reactions was demonstrated in palladium-catalyzed cross-coupling reactions with haloarenes. Cross-coupling reaction of [MeB(OCH₂)₃CCH₃]Li with aryl halides occurred in the presence of Pd(OAc)₂/RuPhos complex in refluxin...

Palladium catalyzed cross-coupling reaction has been developed into one of the most powerful methods for the formation of C-C bonds.1 Recently, remarkable progress has been made in the Pdcatalyzed cross-coupling reactions with carbon nucleophiles derived from active methylene compounds,1d ketones,2 esters,3 amides,4 and nitriles.5 Hydrazones have also been applied in this type of reactions as a...