Vitamin D resistant rickets with alopecia is a rather rare heritable disease probably caused by a different variety of metabolic disorder of this vitamin. Disturbances of protoplasmic and unclear receptors for vitamin D metabolites in bones and intestinal cells have been proposed as basic mechanism; Alopecia is attributed to hypersensitivity to vitamin D; very much like what usually appears in ...

Multiple sclerosis (MS) is a complex neurological disease and its prevalence is about 2 million in the world. Neuroinflammation plays a key role in MS. Vitamins are essential nutrients that have effective role on immune system including activation of lymphocyte and differentiation of T-helper cell. Vitamin D is a micronutrient that is effective on immune function. Deficiently of Vitamin D is a ...

BACKGROUND Dietary supplements providing physiologic amounts of several micronutrients simultaneously have not been thoroughly tested for combating micronutrient deficiencies. OBJECTIVE We determined whether a beverage fortified with 10 micronutrients at physiologic doses influenced the iron and vitamin A status and growth of rural children (aged 6-11 y) attending primary schools. DESIGN In...

Globally, approximately 75% of blind children live in low-income countries (LICs). Almost half of blindness and low vision in LICs is due to avoidable causes such as corneal scarring from measles infection, vitamin A deficiency disorders, use of harmful traditional eye remedies, ophthalmia neonatorum and cataract.

BACKGROUND Model-based compartmental analysis of data on plasma retinol kinetics after administration of labeled retinol provides unique information about whole-body vitamin A metabolism. If labeled β-carotene is coadministered, its bioefficacy relative to the retinol reference dose can also be estimated. OBJECTIVES The objectives were to model plasma retinol kinetics after administration of ...

BACKGROUND Vitamin A can have a positive impact on growth and development of children, but vitamin A deficiency (VAD) was found to be a public health problem in Zhejiang Province, China in 1998. There have been no studies on this topic in Zhejiang Province recently. This study was designed to evaluate the serum retinol levels of children aged 0~4 years in Zhejiang Province, southeast China. Thi...

Seventy-seven wild otters (Lutra lutra) found dead in south west England between 1988 and 1996 were examined post mortem. Liver samples were analysed from 56 otters for polychlorinated hydrocarbons and from 40 for vitamin A (retinol). There was a significant decline in the levels of pollutants over the study period and this coincided with a marked increase in vitamin A levels. However, a causal...

In order to induce a range of vitamin A-deficient states in young growing rats and to study the effect of vitamin A deficiency on Fe status, we designed the following two-generation experiment. Dams were fed on diets with one of five vitamin A levels from 2 weeks before and throughout pregnancy and lactation. The pups received the same diets as their mothers both before and after weaning. The f...

Several studies have indicated a close relationship between vitamin A and protein metabolism. McLaren (1959) found that the onset of vitamin A deficiency in rats could be delayed by reducing their protein intake. Rechcigl, Berger, Loosli & Williams (1962) observed that when rats were given different levels of dietary protein for a 3-week period their total liver stores of vitamin A were inverse...

This study was conducted to examine the possible association between vitamin A status and overnutrition in Chinese urban children and adolescents. Weight, height and serum retinol were assessed in total 3457 children (7-9.9 years of age) and adolescents (10-17 years of age), using urban region data from the China National Nutrition and Health Survey 2010-2013 (CHNNS2010-2013) which is a nationa...