In this paper, a method is presentedfor the efficient estimation of rarecvent (buffer overflow) probabilities in queueing networks using importance sampling. Unlike previously proposed change of measures, the one used here is not static, i.e., it depends on the buffer contenrs at each of the network nodes. The ‘optimal’ statedependent change of measure is determined adaptively during the simuln...

background: myelodysplastic syndromes (mdss) include a diverse group of clonal bone marrow disorders characterized by ineffective hematopoiesis and pancytopenia.it was found that down regulation of apaf1, a putative tumor suppressor gene (tsg),leads to resistance to chemotherapy and disease development in some cancers. in this study, we investigated the relation of apaf1 methylation status with...

Consider a sequence (Xk : k ≥ 0) of regularly varying independent and identically distributed random variables with mean 0 and finite variance. We develop efficient rare-event simulation methodology associated with large deviation probabilities for the random walk (Sn : n ≥ 0). Our techniques are illustrated by examples, including large deviations for the empirical mean and path-dependent event...

In this paper, a method is presented for the efficient estimation of rare-event (buffer overflow) probabilities in queueing networks using importance sampling. Unlike previously proposed change of measures, the one used here is not static, i.e., it depends on the buffer contents at each of the network nodes. The ‘optimal’ state-dependent change of measure is determined adaptively during the sim...

The multiple state transition path sampling method allows sampling of rare transitions between many metastable states, but has the drawback that switching between qualitatively different pathways is difficult. Combination with replica exchange transition interface sampling can in principle alleviate this problem, but requires a large number of simultaneous replicas. Here we remove these drawbac...

In this paper, we introduce a new sampling plan based on the defective proportion of batch. The proposed sampling plan is based on the distribution function of the proportion defective. A continuous loss function is used to quantify deviations between the proportion defective and its acceptance quality level (AQL).  For practical purpose, a sensitivity analysis is carried out on the different v...

In the last decade, significant advances have been made in the treatment of patients with Myelodysplastic Syndromes (MDS). Although best supportive care continues to have an important role in the management of MDS, to date the therapeutic approach is diversified according to the IPSS risk group, karyotype, patient's age, comorbidities, and compliance. Hematopoietic growth factors play a major r...

background: mental disorders may lead to several complications in adolescents’ people whose compensation is very difficult and sometime impossible. they are prone to emotional problems. therefore, knowing prevalence of diseases and valid statistical technique is necessary to plan for prevention and control of diseases. methods: in this cross-sectional study; direct, synthetic, and post-stratifi...

Lenalidomide, an IMiD drug (a novel type of immunomodulating drug) was recently approved by the US Food and Drug Administration for the treatment of transfusion-dependent anemia in patients with myelodysplastic syndromes (MDS) and interstitial deletions of chromosome 5q [del(5q)]. This review examines the clinical experience from the MDS-001 and MDS-003 clinical trials that led to this approval...