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The EGR-1 gene is an immediate early response gene encoding a zinc finger DNA-binding protein. The present studies have examined the regulation of EGR-1 gene expression in human U-937 monocytic leukemia cells treated with granulocyte-macrophage colonystimulating factor (GM-CSF). The results demonstrate that GM-CSF rapidly and transiently increases EGR-1 gene expression in U-937 cells. Similar f...
Lung injury is accompanied by increased deposition of fibronectin (FN) matrices. Activated monocytic cells recruited to sites of lung injury express integrin receptors for FN that mediate their interaction with this matrix. One such integrin, alpha(5)beta(1), mediates many of the biological effects of FN, and its expression may be important for immune cell function at sites of lung injury. Here...
Human U-937 leukemia cells differentiate along the monocytic lineage following 3-day exposures to 12-O-tetradecanoylphorbol-13-acetate (TPA). This induction of differentiation is accompanied by adherence and loss of proliferation, as well as expression/repression of differentiation-associated genes. Long term culture of TPA-differentiated U-937 cells in the absence of phorbol ester for 32-36 da...
Human myeloid differentiation is accompanied by a decrease in cell proliferation. Because the translation rate is an important determinant of cell proliferation, we have investigated translation initiation during human myeloid cell differentiation using the HL-60 promyelocytic leukemia cell line and the U-937 monoblastic cell line. A decrease in the translation rate is observed when the cells a...
of Korea. In traditional medicine, the herb has been used as an expectorant, a diuretic, and an antiinflammatory for bronchitis, rheumatism, skin eruptions, and eczema. Previous phytochemical studies on Viola species have revealed them to be a rich source of cyclotides and several flavone glycosides. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endoproteinases that play pivot...
Lovastatin, an inhibitor of 3-hydroxy.3-methylglutaryl (HMG) CoA reductase, and 6-fluoromevalonate (Fmev), an inhibitor of diphospho mevalonate decarboxylase, blocked the synthesis of downstream meval. onate products, including prenyl-derived lipids, and prevented membrane localization of Ras in the myeloid cell line U.937. In contrast to lovastatin, which induced cytosol localization of Ras in...
Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 932 Goals and objectives. . . . . . . . . . . . . . . . . . . . . 933 Participants . . . . . . . . . . . . . . . . . . . . . . . . . . . 933 Evidence, methodology and validation . . . . . . . . 933 Concept of a "live", modular document . . . . . . . 933 Organisation of the document . . . . . . . . . . . . . . 933 Definition of...
Platelets, activated by various agonists, produce microparticles (MP) from the plasma membrane, which are released into the extracellular space. Although the mechanism of MP formation has been clarified, their biological importance remains ill defined. We have recently shown that platelet-derived MP influence platelet and endothelial cell function. In this study, we have further examined the me...
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