Hodgkin's lymphoma (NHL) are malignant lymphoproliferative diseases arising from a mutant lymphoid cell. Follicular lymphoma is the most common indolent (low-grade) NHL. No cure approach (watch and wait) is recommended for low-grade lymphomas without Bsymptoms. Mono-therapy with chlorambucil or cyclophosphamid is prescribed in case of disease progression. In NHL of high malignancy, especially w...

the brief reports on natalizumab were referred to biogen idec, the manufacturer, which offers the following response: After learning of one confirmed and one suspected case of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab, Biogen Idec and Elan quickly notified the Food and Drug Administration (FDA) and other regulatory authorities. We worked closely with ...

PML caused by John Cunningham (JC) virus is a rare but an increasingly recognized entity. With the advent of newer immunomodulatory therapies with monoclonal antibodies, there is an increasing incidence of PML. Initially concern was restricted to patients treated for multiple sclerosis with natalizumab but more case reports are being reported during treatment for other conditions like Crohn's d...

The radiosensitivity of malignant lymphomas as well as the local targeted delivery of high doses of radiation both make radioimmunotherapy (RIT) an attractive option to fully explore. Radioisotopes are linked to a monoclonal antibody and after intravenous infusion the complex binds to all cells expressing the respective antigen. In this way not only cells binding the radioimmunoconjugate are ki...

High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a standard therapy in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) who are chemosensitive. The combination of carmustine, etoposide, cytarabine, and melphalan (BEAM) is commonly used as a conditioning regimen. The addition of yttrium-90 ((90) Y)-ibritumomab tiuxetan (Zevalin(®)) to BEAM ...