A Fast Fourier Transform method for calculating the three-dimensional dose rate distribution for murine, human-tumor xenografts is outlined. The required input includes evenly-spaced activity slices which span the tumor. Numerical values in these slices are determined by quantitative 125I autoradiography. For the absorbed dose-rate calculation, we assume the activity from both 131I- and 90Y-lab...

The treatment of primary hyperlipidaemic states is reviewed. While several metabolically distinct forms of hyperlipidaemia exist, it is possible to classify patients into three groups for the purpose of therapy. Group 1 is defined as hypercholesterolaemia (due to raised levels of ,8-lipoprotein). In Group 2 the level of endogenous triglyceride is increased, with or without hypercholesterolaemia...

87 Rationale • Ibritumomab tiuxetan (ZevalinTM) is an yttrium 90–labeled anti-CD20 monoclonal antibody. Ibritumomab is the murine counterpart of rituximab, another antibody active in non-Hodgkin’s lymphoma (NHL). It is covalently linked to tiuxetan, which provides a high-affinity chelation site for indium 111 or for 90Y. In phase I/II studies, ibritumomab tiuxetan produced response rates of 67%...

The treatment of primary hyperlipidaemic states is reviewed. While several metabolically distinct forms of hyperlipidaemia exist, it is possible to classify patients into three groups for the purpose of therapy. Group 1 is defined as hypercholesterolaemia (due to raised levels of ,8-lipoprotein). In Group 2 the level of endogenous triglyceride is increased, with or without hypercholesterolaemia...

BACKGROUND The safety and tolerability of sequential radioembolization-sorafenib therapy is unknown. An open-label, single arm, investigator-initiated Phase II study (NCT0071279) was conducted at four Asia-Pacific centers to evaluate the safety and efficacy of sequential radioembolization-sorafenib in patients with hepatocellular carcinoma (HCC) not amenable to curative therapies. METHODS Sor...

BACKGROUND Radiomicrosphere therapy (RT) utilizing yttrium-90 (90Y) microspheres has been shown to be an effective regional treatment for primary and secondary hepatic malignancies. We sought to determine a large academic institution's experience regarding the extent and frequency of gastrointestinal complications. METHODS Between 2004 and 2007, 27 patients underwent RT for primary or seconda...

Objectives: The goals of this investigation are to determine whether commercially available dose calibrators can be used to measure the activity of -emitting radionuclides used in pain palliation and to establish whether manufacturer-supplied calibration factors are appropriate for this purpose. Methods: Six types of commercially available dose calibrators were studied. Dose calibrator response...

The use of radioactive compounds for the treatment of patients with chronic rheumatoid effusion has been proceeding in the Charing Cross Hospital Group since 1968. Initially, a colloidal suspension of radioactive gold (198Au) stabilized with gelatin and glucose was used, and the results in a group of patients whose knees were treated in this way have been published (Grahame, Ramsey, and Scott, ...