Most studies using rabbit or mouse antisera failed to detect CRI between human IgM directed to MAG. We show here that 9 of 10 such IgM express a public CRI as defined by a nonhuman primate antiserum. Shared idiotype is likely involved in (or close to) the combining site of those IgM since antiidiotypic serum inhibited the binding of IgM to MAG and reacted with IgM having different variable regi...

PURPOSE To determine the origin and relationship of the rare IgG+ variant of chronic lymphocytic leukemia (CLL) to the two common IgM+IgD+ subsets that are distinguished by expression of unmutated or mutated V(H) genes, with the former having a worse prognosis. EXPERIMENTAL DESIGN IgG+ CLL cells were characterized using phenotypic, functional, and immunogenetic analyses. RESULTS IgG+ CLL wa...

1 Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M. Biologic and clinical significance of cryoglobulins. A report of 86 cases. Am J Med 1974;57:775–88. 2 Romaszko JP, Tridon A, Jouanel P, Subtil E, Dibet P, Betail G. Détection et analyse des cryoglobulines: étude comparative d’une population de malades et d’une population de témoins sains. Pathol Biol (Paris) 1993;41: 525–9. 3 Tissot JD, Sp...

Two new enzyme-linked immunosorbent assays (ELISA), one for the measurement of immunoglobulin G (IgG) (Captia Syphilis-G) and one for the measurement of IgM (Captia Syphilis-M), were evaluated for detecting antibodies to Treponema pallidum. Serum samples from 169 patients, 96 with various stages of untreated syphilis, 63 with treated syphilis, and 10 who were noninfected, were investigated. All...

والهدف من هذا البحث هو الكشف عن حروف الجرّ التي يتعدّى بها الفعل في كتاب القراءة الوافية المقرّر للصّفّ السّادس والكشف معاني الأفعال المتعدّية بحروف فيه، ولتحقيق الهدف المرجوّ استخدم الباحثون المنهج المكتبيّ حيث قاموا بمطالعة الكتب مما يتعلّق بالأفعال المتعدّية. ولتحليل المسألة البحثية انتهجوا الوصفيّ التّحليليّ وتحليل المحتوى للحصول على النتائج الوثيقة. أمّا نتيجة فهي: أنّ الكتاب المذكور "على" وتتمثل 28 جملة ...

Thirty eight patients with subacute sclerosing panencephalitis (SSPE) were investigated. Five patients who previously had measles immunoglobulin M (IgM) detected in unfractionated serum and cerebrospinal fluid (CSF) had measles IgM exclusively in the low molecular weight (LMW) fractions of serum and CSF. Measles IgM had previously not been found in unfractionated serum from 33 patients but was ...

Recombinant hemagglutinin (H) of the measles virus (MV) expressed in a mammalian high-expression system based on the Semliki Forest virus replicon was used in an enzyme-linked immunosorbent assay (ELISA) for the detection of specific immunoglobulin M (IgM) and IgG in patients with acute-phase measles. One hundred twelve serum specimens from 70 patients with measles were analyzed. Case definitio...